Degree Course: Industrial biotechnology for health and well-being
A.Y. 2020/2021 
Conoscenza e capacità di comprensione
Il laureato magistrale in Biotecnologie Industriali per la Salute e il Benessere, grazie al percorso di studi, acquisisce conoscenze e capacità di comprensione riguardo:
- il metodo scientifico e la sua applicazione;
- la struttura e le funzioni delle molecole e macromolecole biologiche bioattive di interesse salutistico, in armonia con l'ambiente;
- le basi molecolari e cellulari dei sistemi biologici;
- i bersagli molecolari utili alla progettazione e allo sviluppo di biomolecole, di prodotti biotecnologici e di biofarmaci;
- il campo delle biotecnologie animali, vegetali e microbiche per l'individuazione di molecole e processi di impiego industriale;
- gli strumenti analitici tradizionali nel campo delle biotecnologie, incluse le piattaforme tecnologiche specifiche di chimica computazionale e modellistica molecolare, di ingegneria genetica e proteica, delle scienze omiche;
- la chimica delle sostanze bioattive finalizzate alla progettazione e allo sviluppo di molecole ad alto valore aggiunto e alla loro caratterizzazione chimico-fisica, fisiologica e tossicologica;
- le tecniche di fermentazione e di bioconversione per la produzione di molecole di interesse;
- il campo delle metodiche analitiche per il controllo dei processi biotecnologici nel settore industriale.
La verifica del raggiungimento dei risultati di apprendimento sarà effettuata attraverso modalità differenziate volte a coprire aspetti diversi delle attività formative.
Per cui, oltre agli esami orali e scritti, si svolgeranno prove in itinere, relazioni sulle attività di laboratorio comprese le visite didattiche, discussioni di articoli scientifici e seminari degli studenti su argomenti dei corsi.
L'insieme delle attività didattiche teorico-pratiche fornisce allo studente la possibilità di accrescere le proprie conoscenze e di sviluppare la propria capacità di comprensione e di comunicazione scientifica.
Capacità di applicare conoscenza e comprensione
Sulla base delle conoscenze acquisite durante il percorso degli studi, i laureati magistrali sapranno tradurre sul piano pratico e industriale le conoscenze teoriche avendo acquisito capacità critiche e metodologiche per la risoluzione di specifici problemi nell’ambito della biologia applicata e della biotecnologie industriali di interesse salutistico.
Dopo aver acquisito il rigore del metodo scientifico sperimentale e le capacità di ragionamento logico deduttivo e la capacità di elaborare statisticamente i dati biologici, lo studente potrà affrontare e risolvere qualunque nuovo problema inerente la propria professionalità (problem solving attitude).
Inoltre, attraverso attività pratiche prevista nell’ambito dei singolo insegnamenti, i laureati acquisiscono la capacità di utilizzare numerose tecniche di laboratorio, le piattaforme tecnologiche specifiche di chimica computazionale e modellistica molecolare, di ingegneria genetica e proteica, delle scienze omiche, utili allo sviluppo di approcci biotecnologici e biocatalitici in campo industriale.
La capacità di applicare conoscenza e comprensione è raggiunta dagli studenti anche grazie alle attività di laboratorio che prevedono lo svolgimento di esercitazioni individuali in cui ogni studente è in grado di verificare le conoscenze acquisite, comprendendone l'applicazione tramite protocolli di laboratorio, sotto la supervisione del docente.
Estremamente utili ai fini della capacità di applicare conoscenza e comprensione sono anche tutte le attività pratiche collegate agli insegnamenti, comprese le escursioni didattiche, le attività di tirocinio e di tesi sperimentale che rappresenterà un approfondimento di una o più discipline affrontate durante il corso di studi.
Autonomia di giudizio
L'ampia parte di percorso formativo dedicata all'attività pratica di laboratorio consente agli studenti di affrontare attivamente e criticamente i molteplici aspetti di cui si compongono le moderne biotecnologie industriali finalizzate alla salute e il benessere.
Sulla base di questa esperienza, delle nozioni apprese nei corsi di insegnamento, dello svolgimento del tirocinio e della tesi sperimentale che prevede un internato/frequenza di laboratorio e la redazione della tesi di laurea, i laureati devono acquisire autonomia di azione e di giudizio trasferibili a contesti diversi di ricerca, ricerca e sviluppo o produzione che si basata su:
- competenza nella definizione e progettazione di attività sperimentali finalizzate allo sviluppo e/o gestione di processi biotecnologici per l’ottenimento di prodotti di interesse industriale e commerciale;
- capacità di scelta delle tecniche biomolecolari, biologiche, strumentali, computazionali e delle procedure sperimentali idonee alla caratterizzazione strutturale e funzionale delle diverse molecole bioattive e biosistemi;
- capacità nella raccolta, elaborazione ed interpretazione dei dati sperimentali e confronto con fonti bibliografiche opportunamente reperite e vagliate.
L'autonomia di giudizio sarà verificata in occasione delle attività pratiche di laboratorio, delle prove di esame e della prova finale.
Abilità comunicative
I laureati magistrali in Biotecnologie Industriali per la Salute e il Benessere sono in grado di comunicare in maniera chiara e univoca, in forma scritta, parlata e attraverso l'impiego di risorse informatiche e con sistemi multimediali, le attività di ricerca, i risultati scientifici ottenuti, ad esempio durante l’attività di tesi di laurea, e di sostenere una discussione critica sugli argomenti trattati.
Inoltre, i laureti sono in grado di comunicare in modo chiaro le caratteristiche strutturali e funzionali dei sistemi biologici e delle biomolecole e gli aspetti impiantistici e di processo delle biotecnologie industriali anche a interlocutori non specialisti.
I laureati sanno comunicare tematiche di tipo biologico, biotecnologico e bio-industriale anche in lingua inglese, in forma scritta e parlata.
In particolare, le abilità comunicative saranno verificate al momento dello svolgimento delle prove di esame, durante l’internato/frequenza di laboratorio per lo svolgimento del lavoro di tesi, infine, nella redazione e discussione della tesi di laurea.
Capacità di apprendimento
I laureati magistrali in Biotecnologie Industriali per la Salute e il Benessere hanno capacità di approfondire tematiche complesse nel campo delle biotecnologie e alla biologia applicata.
Devono, quindi, saper lavorare in modo autonomo e di proseguire autonomamente gli studi a livelli di formazione superiori in campo biotecnologico (master e dottorato di ricerca).
Queste capacità sono conseguite con lo studio individuale dei singoli insegnamenti e durante la preparazione della tesi di laurea magistrale.
La capacità di apprendimento viene verificata in occasione delle prove di esame e della prova finale.
Requisiti di ammissione
Per essere ammessi al corso di Laurea Magistrale in Biotecnologie Industriali per la Salute e il Benessere (LM-8) occorre essere in possesso di una laurea triennale (o quinquennale) o di altro titolo di studi equipollente conseguito all'estero.
In particolare, l'accesso è consentito a tutti coloro che sono in possesso di una laurea triennale nella classe L-2 e L-13 (o loro ordinamenti previgenti) o anche a quanti hanno acquisito un minimo di 36 CFU in almeno 6 dei seguenti settori scientifico disciplinari: CHIM/03, CHIM/06, CHIM/11, BIO/10, BIO/11, BIO/18, BIO/19, AGR/13, AGR/07 e AGR/16.
Costituisce requisito d'accesso anche un'adeguata conoscenza della lingua inglese (livello B1).
I laureati in possesso di tali requisiti dovranno sostenere una prova di verifica della preparazione personale, secondo la modalità di seguito illustrata: colloquio orale oppure in forma di test che verterà sulle conoscenze di base e sulle competenze acquisite per le discipline di Biochimica, Biologia molecolare, Genetica, Microbiologia ed Inglese B1.
La prova potrà tenersi in varie sessioni secondo un calendario che verrà pubblicato annualmente.
Prova finale
La prova finale costituisce un momento formativo individuale fondamentale nel percorso di Laurea Magistrale e consiste nella redazione, anche in lingua inglese, e nella discussione di una tesi scritta elaborata in modo originale dallo studente su un argomento coerente con gli obiettivi del corso di studio, sotto la guida di un relatore.
Durante il lavoro sperimentale, lo studente acquisisce conoscenze sulle metodologie sperimentali e sul metodo di indagine scientifico, nonché di analisi ed elaborazione dei dati.
Con la dissertazione di fronte ad una Commissione di Laurea nominata dal Direttore di Dipartimento, lo studente deve dimostrare la padronanza degli argomenti, capacità critica, l'attitudine a operare in modo autonomo e una capacità di comunicazione di buon livello.Orientamento in ingresso
Le attività di orientamento in entrata realizzate dall'Università degli Studi della Tuscia di Viterbo si collocano a livello centrale (Ateneo) e periferico, che nel caso del CdS LM-8 sono i due Dipartimenti che contribuiscono alla gestione del CdS interdipartimentale, il DIBAF e il DEB.
Il DIBAF, dipartimento di afferenza del corso di studio in Biotecnologie L-2 e Biotecnologie Industriali per la Salute e il Benessere (LM-8), in genere programma annualmente diverse attività di supporto e informazione agli studenti per consentire una scelta informata e consapevole del proprio percorso universitario.
Il Dipartimento ha individuato un referente per le attività di orientamento in ingresso che svolge un ruolo di coordinamento delle stesse; anche il CdS ha un proprio referente che, insieme al coordinatore del CdS, partecipa alla organizzazione delle attività di orientamento in ingresso.
Anche il DEB, l'altro dipartimento coinvolto nella gestione del CdS, avrà un ruolo attivo in tutto questo.
In particolare, l'orientamento in ingresso si realizza attraverso le seguenti attività:
a) ogni anno accademico, l'Ateneo e i Dipartimenti organizzano due giornate di orientamento (Open Day).
In queste occasioni vengono presentati il Dipartimento e i vari Corsi di Laurea.
Seguono incontri di approfondimento con i Coordinatori dei corsi di studio;
b) organizzazione di specifiche attività con le Scuole secondarie superiori duranti i quali si illustrano i CdS e le cosiddette “filiere formative” illustrando percorsi 3+2 che includono quindi anche le laurea magistrali che rappresentano opportunità di prosecuzione degli studi e che guidano la scelta anche del CdS triennale;
c) organizzazione di attività di orientamento alla scelta della laurea magistrale a livello di dipartimento e di ateneo che mirano ad illustrare nel dettaglio agli studenti delle lauree triennali l'offerta formativa, gli sbocchi occupazionali e il profilo professionale del laureato magistrale;
d) sportello di orientamento attivato dal DIBAF, a cui rivolgersi per acquisire informazioni sull'offerta formativa e sui servizi del Dipartimento di afferenza del CdS (DIBAF) e del DEB;
e) partecipazione dei docenti a saloni / manifestazioni di orientamento di carattere nazionale o regionale, a giornate aperte ed eventi culturali organizzati nel territorio, finalizzati a presentare in modo ampio e dettagliato i percorsi formativi offerti dalla struttura didattica;
f) organizzazione di una giornata, per gli studenti iscritti al primo anno della laurea magistrale, finalizzata alla presentazione dei singoli insegnamenti e delle attività di ricerca che si svolgono al latere degli stessi, visto che la formazione è strettamente legata alla ricerca ed alla sua mutabilità in termini di crescita di informazioni, modalità di indagine e gestione dei risultati.
Per lo svolgimento delle attività di orientamento la struttura didattica si avvale del supporto degli studenti senior e dei dottorandi selezionati in base a concorsi banditi dalla strutture stesse per il conferimento di assegni per attività di tutorato e orientamento (i cosiddetti studenti-tutor).
Il Corso di Studio in breve
In un quadro generale di riferimento in cui la qualità, l’origine e la sostenibilità delle produzioni industriali finalizzate ai settori cosmetico, cosmeceutico, nutraceutico e farmaceutico risultano sempre più di maggiore interesse del consumatore, dell’industria e del mercato, l’estrazione, la produzione e la caratterizzazione chimico-biologica da un punto di vista strutturale, funzionale e fisiologico di molecole bioattive, a medio ed alto valore aggiunto, diventa fondamentale.
Questo impone una visione olistica e multi-disciplinare delle biotecnologie industriali dedicate alla salute ed il benessere che deve tenere conto della sostenibilità dei processi e delle aspettative dei consumatori che sono sempre più attenti alla qualità e alla tutela dell’ambiente; in questo contesto, l’utilizzo di risorse rinnovabili (economia circolare) e di processi biotecnologici è imprescindibile.
La salute ed il benessere dell'uomo sono quindi posti al centro dell’attenzione dei mercati futuri nella pianificazione strategica dello sviluppo industriale della Comunità Europea e della Comunità Internazionale.
La Laurea Magistrale in Biotecnologie Industriali per la Salute e il Benessere mira a formare laureati che siano in grado di progettare, produrre e/o recuperare molecole bioattive di origine vegetale, animale, microbica e di semi-sintesi con interesse cosmetico, cosmeceutico, nutraceutico e farmaceutico.
Lo studente del CdS è, quindi, chiamato ad apprendere le metodologie scientifiche avanzate necessarie per lo studio e lo sviluppo dei processi di estrazione delle sostanze naturali, di caratterizzazione delle molecole bio-attive e di progettazione di nuove sostanze con effetti biologici mirati, della determinazione del loro effetto farmacogenetico e tossicologico, e della realizzazione di sistemi biomolecolari, biocatalitici e dei bioprocessi microbiologici fondamentali per concretizzare l'impiego delle biotecnologie nel mondo della ricerca applicata, delle produzioni industriali e dei servizi correlati alla salute ed il benessere dell’uomo.
Il CdS magistrale è articolato in un pacchetto di 8 insegnamenti obbligatori e di 3 insegnamenti opzionali da scegliere fra un gruppo di 7, oltre a 12 CFU di attività formative a scelta (AFS) ed un insegnamento di inglese B2.
Il percorso, connotato da attività pratiche di laboratorio presso strutture che svolgono collaborazioni con il mondo industriale, consente di fornire elevate competenze di base ed applicate, per approfondire aspetti altamente professionalizzanti.
Lo studente espliciterà le proprie scelte al momento della presentazione,
tramite il sistema informativo di ateneo, del piano di completamento o del piano di studio individuale,
secondo quanto stabilito dal regolamento didattico del corso di studio.
FIRST YEAR
First semester
Course
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Credits
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Scientific Disciplinary Sector Code
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Contact Hours
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Exercise Hours
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Laboratory Hours
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Personal Study Hours
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Type of Activity
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Language
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18432 -
Biochemical characterization of pharmacologically active molecules
(objectives)
The course will be focused on the most innovative principles and experimental approaches regarding the production of proteins to be used in biotechnological approaches related to human health. The course will also extend the knowledge on aspects related to the relation between the structure and the biological activity of the proteins pharmacologically active. Particular emphasis will be paid on antimicrobial peptides and on the applications of antibodies in diagnosis and as new drugs.
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6
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BIO/10
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40
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-
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8
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-
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Core compulsory activities
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ITA |
18434 -
Microbial biotechnologies
(objectives)
The course aims to prepare students with adequate knowledge of the industrial and environmental microbial processes. the study of microorganisms in applications aimed at improving the quality of life, reducing the impact of human activities on the environment and recovering degraded environments. The course will also allow the acquisition of techniques for the control of microbial processes and molecular methodologies for the analysis of microbial communities
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6
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BIO/19
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40
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-
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8
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-
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Core compulsory activities
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ITA |
18435 -
Biostatistics and analysis of experimental data
(objectives)
Educational goals The course aims to provide the tools necessary to analyze the experimental data using the most appropriate statistical analysis tools, with the help of theoretical lessons, practical lessons and use of software. At the end of the course the students will be able to analyze experimental data.
Expected learning outcomes KNOWLEDGE AND UNDERSTANDING At the end of this educational activity, in a context of exercise or examination, the student must demonstrate that he has acquired the knowledge of the basic elements of the statistics and development of the ability to analyze the data related to experimental studies in the field of biotechnology, in agreement with as foreseen by the program.
ABILITY TO APPLY KNOWLEDGE AND UNDERSTANDING At the end of this educational activity, the student must demonstrate that he / she understands the statistical and data analysis approaches and that he / she can choose the most suitable ones to solve problems of interest, analyzing the results in a critical way.
JUDGMENT AUTONOMY At the end of the training activity the person must be able to analyze and interpret the experimental results obtained and discuss them logically.
COMMUNICATION SKILLS The student must demonstrate that he / she is able to have acquired the necessary communication skills to disseminate the results of the experiments and analyzes conducted using appropriate forms of communication based also on the use of IT tools according to the type of interlocutors.
LEARNING SKILLS At the end of this training activity, the student must demonstrate to be able to use the knowledge learned to investigate systems and phenomena of interest, different from those taken into consideration during the course.
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6
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SECS-S/02
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32
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16
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-
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-
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Core compulsory activities
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ITA |
18437 -
Spectroscopic and computational methods for the study of biomolecules
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|
-
Metodi spettroscopici
(objectives)
The spectroscopic methods course is designed to provide basic knowledge of the experimental approaches of spectroscopy to the biological sciences. The program seeks to provide students with an understanding of UV, Fluorescence, CD and NMR spectroscopy.
LEARNING OUTCOMES
KNOWLEDGE AND CAPACITY OF COMPREHENSION: Basics of spectroscopy applied to the study of biological systems.
CAPACITY TO APPLY KNOWLEDGE AND COMPREHENSION: Starting from the examples discussed during the course, students should be able to apply different theoretical-experimental approaches to solving problems and apply the different spectroscopic techniques.
AUTONOMY OF JUDGMENT: Students should be able to understand and analyze experimental and computational data and discuss them logically.
LEARNING CAPACITY: Students should be able to describe scientific issues applied to bio-molecular systems by critically using the methodologies and techniques discussed in the course.
COMMUNICATIVE SKILLS: Students should be able to communicate scientific issues in the field of spectroscopy applied to biological systems.
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6
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CHIM/02
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48
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-
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-
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-
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Core compulsory activities
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ITA |
-
Metodi computazionali
(objectives)
The module aims is to provide an overview of the methods and techniques which are used within modern molecular modeling to study molecular and biomolecular systems. The module of Computational Methods consists of both theoretical lectures and practical computer exercises.
Learning achievements: KNOWLEDGE AND UNDERSTANDING: understand the principles of computational methods presented in the course. The student should be able to understand the potentialities and the use of computational methods for the study of biological systems.
CAPACITY TO APPLY KNOWLEDGE AND COMPREHENSION: Understanding of the theoretical aspects of computational methods in order to choose the most suitable computational technique for studying the system of interest.
AUTONOMY OF JUDGMENT: the student must be able to interpret the results obtained by molecular modeling calculation and discuss them logically.
COMMUNICATIVE SKILLS: The student must have developed a good oral exposure capacity of the acquired concepts.
LEARNING CAPACITY: The student must be able to describe the properties of the biomolecular systems by critically using the techniques discussed in the course.
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3
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CHIM/07
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24
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-
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-
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-
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Related or supplementary learning activities
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ITA |
18438 -
Industrial catalysis and biocatalysis
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|
-
Principi di catalisi
(objectives)
This course aims to provide students with the general concepts related to the chemical aspects of catalysis and its applications in the biological and biotechnological fields. Starting from the fundamental aspects of chemical kinetics, a path will be developed which will result in the student being able to discuss the reaction mechanism of some processes of biotechnological interest, identifying the possible catalytic nature of the same and critically discussing the various phases and possible industrial applications.
1) Knowledge and understanding: acquisition by the student of specific contents relating to: i) general principles of chemical kinetics and catalysis; ii) identification of catalytic processes of biotechnological interest, with detailed description of the various phases; iii) placement of the systems studied in the more general context of catalysis and industrial biocatalysis. 2) Ability to apply knowledge and understanding: the student's ability to analyze, in the light of the knowledge acquired, the possible interest, even on a large scale, of a catalytic process, both natural and summary, critically examining the various phases and any application objectives. 3) Making judgments; the teaching will provide the student with the ability to work independently in judgment, also through critical consultation and comparison of teaching materials of various types. In any case, the ability of the individual to interact critically with the other components of a homogeneous class will be developed, stimulating in particular the interaction between the components of the same. 4) Communication skills: the student who attends the course will be continuously asked to illustrate, also through audiovisual techniques, the progress made in the study of the discipline and in the learning of the presented concepts. The teacher will also stimulate the discussion also through an exchange of opinions between the attending students, who will thus become an active part in the process of communication and elaboration of the individual. 5) Ability to learn (learning skills): it will be constantly stimulated also through the administration of tests and exercises to be performed autonomously, with the aim of restoring the results and comparing them with those obtained by students attending the same class. Class exercises and simulations of the final test will also be carried out.
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3
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CHIM/03
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24
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-
|
-
|
-
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Related or supplementary learning activities
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ITA |
-
Biocatalisi industriali
(objectives)
Knowledge and understanding The course aims to provide students with the theoretical and application bases related to the use of biocatalytic systems applied to various industrial sectors. A broad overview is offered of processes assisted by biocatalysts characterized by real commercial relevance
Ability to apply knowledge and understanding The student will acquire from the course the guidelines in the selection of the catalyst, of the possible immobilization method and of the most suitable reactor configuration for the target application. Furthermore, he will be in possession of elements that allow him to make a targeted choice between possible alternative commercial formulations containing the enzyme in question, based on information provided by the manufacturer and the scientific literature.
Expected learning outcomes Basic knowledge of current applications of enzymes in the free or immobilized form in industrial biocatalysis.
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3
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AGR/13
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24
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-
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-
|
-
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Related or supplementary learning activities
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ITA |
Second semester
Course
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Credits
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Scientific Disciplinary Sector Code
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Contact Hours
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Exercise Hours
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Laboratory Hours
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Personal Study Hours
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Type of Activity
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Language
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18430 -
Applied omics sciences
(objectives)
TRAINING OBJECTIVES
1) Homics is a set of biomolecular disciplines that belongs to the life sciences and which is divided into different themes (genomics, transcriptomics, proteomics, metabolomics). The main objective of the course is to enable the student to face the study of the main analytical techniques and instruments by deepening his knowledge of modern omic analyzes, essentially applied to a modern vision of early diagnosis. The student will be prepared to face the search for new diagnostic markers in clinical and non-clinical analyzes. At the end of the lectures, during the scheduled workshop (24h), students are given the opportunity to work individually on practical and practical topics. In this way, the student will acquire the ability to analyze the different protein expression starting from protein extracts and the possibility of applying modern analytical tools.
b) EXPECTED LEARNING RESULTS:
1) Knowledge and understanding: Having acquired a good analytical ability in the field of omics and biotechnology
2) Knowledge and applied comprehension skills: Knowing how to integrate the knowledge acquired in the individual disciplines into an interdisciplinary knowledge necessary to face any complex problem in the biotechnology sector, in particular being able to apply the knowledge of mass spectrometry to the various applications related to biotechnology.
3) Autonomy of judgment Students will have to develop the ability to process complex and / or fragmentary information and to arrive at original and autonomous ideas and judgments capable of finding and critically selecting sources of bibliographic data, databases, and the scientific literature. The autonomy of judgment is developed through the critical study of scientific articles.
4) Communication skills: The student will be able to hold a critical public discussion on the topics covered in particular will be able to apply proteomics and metabolomics techniques for any scientific topic of interest .. Will be able to work in a team in the field of design and execution of experimental protocols as laboratory credits are foreseen.
5) Ability to learn: The student will have the ability to identify, apply and develop innovative techniques in the relevant field of work autonomously.
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6
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BIO/11
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24
|
24
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-
|
-
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Core compulsory activities
|
ITA |
18431 -
Genetic toxicology
(objectives)
LEARNING OBJECTIVES Genetic toxicology has developed as a discipline independent of Genetics with the aim of defining a robust programme to control the spread of chemical, physical and biological mutagenic agents in the environment. The discovery of an increasing number of mutagenic substances already present or continuously introduced in the environment and the confirmation of the increasingly close correlation between mutagenic processes, carcinogenesis and hereditary genetic diseases, has led to the development of laboratory methods capable of identifying mutagenic substances and the development of monitoring systems to assess the onset of genetic effects in the human population. The aim of the class is to acquire basic knowledge related to the metabolism of xenobiotics, the action of ionizing radiation and biological mutagens and the interaction between mutagenic agents and hereditary material. At a later stage, the theoretical and practical aspects of the main short-term mutagenicity tests will be presented. EXPECTED LEARNING OUTCOMES 1) Knowledge and understanding: • Knowledge of the fundamental dynamics of the generation of genetic mutations through the different mechanisms of formation of "primary lesions" to DNA, consequent DNA repair processes and final fixation of the mutations; • Knowledge of the phenotypic effects of mutations at the somatic level (individual), in relation to the development of neoplasms and/or degenerative conditions such as premature ageing, immune, cardiovascular and neurodegenerative dysfunctions and mutations at germinal level (transgenerational effects) related to hereditary genetic diseases; •Knowledge of the interindividual (human) effects induced by mutagens in relation to the different metabolic capacities regulated by polymorphic metabolic genes (P-450); •Acquisition of the ability to use "in silico" methodologies (QSAR models) that allow to establish the relationships between the chemical structure of a substance and the specific properties or activities of the compound itself (e.g. sensitization, genotoxicity, carcinogenicity).
2. Applying knowledge and understanding: •Identification of appropriate "mutagenesis test batteries" selection strategies for an efficient and correct definition of the genotoxic potential of a specific agent (natural active substances, synthetic and biotechnological drugs, food additives, agrochemicals, biocides, etc.) at the three fundamental levels of genetic material organization (gene, chromosomal and genomic) and a possible "risk assessment" for humans.
3. Making judgements: •The teaching will provide the student with the ability to work autonomously by providing appropriate types of teaching materials (lectures in the form of presentations, specific monographs, relevant scientific literature, computer platforms) and the performance of appropriate laboratory activities synchronized with the theoretical part of the course.
4. Communication skills: •Students will be appropriately stimulated to actively participate in the activities of course and to design and solve specific scenarios related to the different evolutionary phases of the class. In this regard, in the final phase of the laboratory activities, students will identify autonomously a "model" of a mutagenic agent and its assay strategy.
5. Learning skills: The students' learning skills will be evaluated in progress and verified through the ability to solve relevant and specific scenarios of interest, different from those proposed during the class.
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6
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BIO/18
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40
|
-
|
8
|
-
|
Core compulsory activities
|
ITA |
18436 -
Chemistry of bioactive substances
(objectives)
EXPECTED LEARNING RESULTS
• Knowledge and understanding: Knowledge of the principles that define the minimum structural unit of an organic, natural or synthetic molecule, to have a certain biological activity (pharmacophore theory). Knowledge of the relationship between the type of pharmacophore present in an organic molecule and the pharmaceutical and pharmacological activity. Knowledge ot the molecular-level of the action mechanism of the major families of bioactive substances, with particular attention to substances with antioxidant, antiviral, anti-inflammatory and antitumour activity. Knowledge of the key steps for the design of a drug, and procedures for its clinical validation and use. Knowledge of the origin and distribution in nature of the main families of biologically active natural organic substances. • Applied knowledge and understanding: In addition to the knowledge gained through the bioactive substance chemistry study, students will be able to apply theoretical concepts acquired during the course in solving practical exercises based on the teacher's request to present possible schemes for the design of a drug, having the initial indication of the target of action at the molecular level and knowing the type of pathology against which the treatment therapy is to be developed. In this case, students will also have to apply their previous knowledge of chemistry and biology for complete resolution of the problem. • Making judgements: At the end of the course, the student will have acquired the necessary training for full autonomy of judgment on the possibility of using a certain organic substance of natural or synthetic origin for the therapy of a certain pathology . The student will then be able to link the acquired knowledge of biochemistry, molecular biology, enzymology, physiology and genetic to the design of a substance applicable in the pharmaceutical, nutraceutical and cosmeceutical fields. • Communication skills: students will be continuously and consistently invited to participate actively in the lesson in order to deepen the topic and to collect proposals for possible solutions in the case of complex phatological scenarios. In this activity, students will be called upon to meet in order to support their ideas. The educational pitch is aimed at increasing the communicative skills and the ability to know how to work and to confront a group, all aimed at consolidating the acquired concepts. • Learning Skills: Students' learning abilities will be evaluated during the course of the course by tests that will allow to individually monitor the maturation state of the knowledge, highlighting the student's ability to return the aquired cencepts.
|
6
|
CHIM/06
|
48
|
-
|
-
|
-
|
Core compulsory activities
|
ITA |
18447 -
English language B2
(objectives)
The English language course aims to familiarize students with the techniques of writing in the English language which differs from writing in Italian. This course also allows students to produce documents and/or short essays which are relevant for their course of study. The course therefore focuses on two of the four language skills - writing and reading - without forgetting listening and speaking. To achieve these objectives, classes are exclusively taught in English. It is for this reason that the grammatical basis of the language and its phonological aspects are not neglected but analyzed whenever the need arises. The final goal is the achievement of level B2 of the Common European Framework of Reference (CEFR), adopted by the Council of Europe by means of which the student: * Can understand the main ideas of complex text on both concrete and abstract topics, including technical discussions in his / her field of specialization. * Can interact with a certain fluency and spontaneity that make natural interaction with native speakers possible without effort for the interlocutor. * Can produce clear and detailed text on a wide range of topics and explain a point of view on a topic providing the pros and cons of the various options. These objectives are achieved by developing and consolidating the four language skills but above all applying the linguistic knowledge that is gradually being acquired. Particular attention is paid to the text and context; text analyzes are carried out to identify the specific and pertinent vocabulary, the register to be used and the method of outlining and writing an essay. Texts of various topics are submitted to students but the main focus is on on scientific topics, crucial to their course of study; also audio will be distributed to develop the ability of oral comprehension; moreover, at each lesson, students must prepare and present some topics of interest in Power Point version.
|
4
|
L-LIN/12
|
32
|
-
|
-
|
-
|
Other activities
|
ITA |
18448 -
Stage
|
3
|
|
-
|
-
|
-
|
-
|
Other activities
|
ITA |
SECOND YEAR
First semester
Course
|
Credits
|
Scientific Disciplinary Sector Code
|
Contact Hours
|
Exercise Hours
|
Laboratory Hours
|
Personal Study Hours
|
Type of Activity
|
Language
|
Optional Group:
gruppo OPZIONALE affini e integrativi - (show)
|
18
|
|
|
|
|
|
|
|
18444 -
Sustainable biorefineries and biotechnologies
(objectives)
A) OBJECTIVES The aim is to provide students with the knowledge on the concept of bio-refinery and the impact that it will have in the development of industrial biotechnology. Besides the identification of criteria on which is based the development of bio-refineries will be analyzed several examples of production of fine-chemicals, biomolecules and enzymes through the recovery and purification from natural matrices or by fermentation. B) EXPECTED LEARNING RESULTS 1) Knowledge and understanding will be acquired by the student in relation to: i) eco-compatible biotechnology for the protection of the environment, also in view of the recovery of biomolecules of potential health interest, as in the case of bioraffinerie ; (ii) environmentally friendly methods for the protection of the environment and for the exploitation of natural resources currently disposed of with waste or wastewater; (iii) biotechnological approaches designed to produce molecules of potential interest, for example in pharmacology, nutraceuticals and / or cosmetics; iv) ability to use English, particularly in technical and scientific contexts. 2) Applied knowledge and understanding will cover the ability to design and use microorganisms for biotechnological purposes in the treatment of residual waste and wastewater with the aim of obtaining high added value products and defining research design in the field of industrial and pharmaceutical biotechnology. 3) Making judgements; the teaching will provide the student with the ability to work autonomously, in particular through the critical consultation of various types of teaching materials (such as scientific publications in English, position papers, etc.) and the carrying out of laboratory activities and teaching visits. 4) For communication skills, the student who attends the teaching will be able to present biotechnologies related to microbial biotechnology and bio-refineries, with the help of appropriate audiovisual techniques and critically. This ability will also be achieved thanks to the extensive use of power point presentations in the classroom and to the dialogue and exchange of views between the students and the teacher both during frontal lessons and during laboratory activities and didactic excursions. 5) Learning skills would be acquired through autonomous learning of application issues addressed in teaching and during laboratory exercises.
|
6
|
BIO/19
|
40
|
-
|
8
|
-
|
Related or supplementary learning activities
|
ITA |
18445 -
Functional foods
(objectives)
The aim of the course is to provide students with the information needed to understand the theoretical / practical bases of food science and, in particular, the evolution that this subject has undergone over the years. In fact it no longer deals only with satisfying the nutritional needs of the individual but tends to be a means for the prevention and treatment of some diseases. In this course then it will be about functional foods pointing out that part of the classic and modern diet and the experimental approaches that have allowed its evolution. Students will have to learn the meaning of functional foods and novel foods as well as learn which criteria and which technological approaches to use to improve food quality. Finally, the course aims to provide the basis for further in-depth studies in the field of foods and their effect on the human organism. The topics concerning nutrigenetics and nutrigenomics will also be addressed.
Expected learning outcomes
Knowledge and understanding: To have developed the knowledge of the principles of classic food science and some dietary principles. Furthermore, the relationship between diet and health should be clear in order to bring this knowledge into the process of food transformation and improvement. Have communication skills in the field of Food Science Ability to apply knowledge and understanding: the student should be able to use the knowledge acquired to work in the food industry and in particular in the field of functional foods. Making judgments: Being able to improve the quality of food and to identify new ingredients for the development and food with high health properties. Communication skills: The students' ability to talk, reason and discuss the questions raised during the lessons on the topics discussed will be stimulated. Learning skills: Being able to discuss scientific topics concerning food science also in its bio-medical applications and its implications in the food industry. This skill will be developed and tested by involving students in oral discussions in the classroom.
|
6
|
MED/49
|
40
|
-
|
8
|
-
|
Related or supplementary learning activities
|
ITA |
18443 -
Pharmacogenetics
(objectives)
TRAINING OBJECTIVES The teaching is aimed at providing students with the basic notions for understanding the genetic and molecular bases of pharmacogenetics and pharmacogenomics, this last the disciplines that aim to identify the genes and gene variants that determine the inter-individual variability in the response to drugs.
EXPECTED LEARNING RESULTS - have gained knowledge of drug-organism interactions (molecular and cellular) that determine the efficacy or toxicity of drug treatment and the role of interindividual genetic variability (primarily genetic polymorphisms) in determining the variability of response to the drug; - being able to apply the knowledge developed to understand specific cases; - being able to express oneself with appropriate scientific terminology - having developed the ability to understand and describe experiments, which contributed to the understanding of the genetic basis of pharmacological treatment.
|
6
|
BIO/18
|
40
|
-
|
8
|
-
|
Related or supplementary learning activities
|
ITA |
18440 -
Biotechnology of animal molecules
|
Also available in another semester or year
|
18439 -
Biotechnology of plant molecules
|
Also available in another semester or year
|
18441 -
Industrial applications of microscopic techniques
|
Also available in another semester or year
|
118976 -
Nutrition Physiology
|
Also available in another semester or year
|
|
18446 -
Free exam
|
12
|
|
96
|
-
|
-
|
-
|
Elective activities
|
ITA |
Second semester
Course
|
Credits
|
Scientific Disciplinary Sector Code
|
Contact Hours
|
Exercise Hours
|
Laboratory Hours
|
Personal Study Hours
|
Type of Activity
|
Language
|
Optional Group:
gruppo OPZIONALE affini e integrativi - (show)
|
18
|
|
|
|
|
|
|
|
18444 -
Sustainable biorefineries and biotechnologies
|
Also available in another semester or year
|
18445 -
Functional foods
|
Also available in another semester or year
|
18443 -
Pharmacogenetics
|
Also available in another semester or year
|
18440 -
Biotechnology of animal molecules
(objectives)
Knowledge, understanding and judgment skills of basic and applied subjects pertaining cellular and molecular biology techniques applied to animal biotechnologies. Development of critical and communication skills based on specialized scientific publications.
|
6
|
BIO/05
|
40
|
-
|
8
|
-
|
Related or supplementary learning activities
|
ITA |
18439 -
Biotechnology of plant molecules
(objectives)
The aim of the Course is to provide to the students an overview on plant-based molecules and their applications for transformation into consumer goods. Particular attention will be paid to the use of plant-based molecules as active ingredients for pharmaceuticals. The Course will also investigate methodologies for the chemical and biological characterization of molecules of plant origin. A research procedure will be simulated and the results described in a scientific report.
|
6
|
BIO/01
|
40
|
-
|
8
|
-
|
Related or supplementary learning activities
|
ITA |
18441 -
Industrial applications of microscopic techniques
(objectives)
EXPECTED RESULTS KNOWLEDGE AND UNDERSTANDING: By the end of the module, students will be expected to know microscopy techniques and their biological and biomedical applications. APPLYING KNOWLEDGE AND UNDERSTANDING: Applying advanced microscopic methods to specific biotechnological issues. MAKING JUDGEMENT: Analyzing and interpreting experimental results. COMMUNICATION SKILLS: Ability to describe scientific problems, methodological approaches and results in the biotechnological field using the appropriate scientific language. LEARNING SKILLS: Students will be expected to develop the ability to learn independently applied scientific topics and methodological approaches.
|
6
|
BIO/05
|
24
|
-
|
24
|
-
|
Related or supplementary learning activities
|
ITA |
118976 -
Nutrition Physiology
(objectives)
a) FORMATIVE OBJECTIVES Understanding the basic elements of the physiology and neurophysiology of feeding and, in particular, describing: the functional mechanisms of the gastrointestinal tract (oral cavity, esophagus, stomach, liver, intestines) including transport processes, motility, secretion, excretion, digestion and absorption; their control by central/peripheric nervous system and by autocrine, paracrine and endocrine components; the regulation of the metabolic processes associated with the ingestion of nutrients and the energy balance; the fundamental (neuro)physiological principles behind eating behavior.
b) EXPECTED LEARNING RESULTS (Dublin Descriptors) KNOWLEDGE AND UNDERSTANDING CAPACITY: To pass the exam, the student will have to demonstrate that she/he has gained a knowledge and ability to understand the issues related to the functioning of the gastrointestinal tract and its components and the (neuro)physiological processes of nutrients ingestion that will allow her/him to set the discussion of theoretical issues in logical and complete way. CAPACITY TO APPLY KNOWLEDGE AND COMPREHENSION: The student will have to demonstrate how to set up applicative problems in the field of Nutrition physiology. AUTONOMY OF JUDGEMENT: The student must have acquired such knowledge as to enable her/him to describe the mechanisms underlying the cell and body functions and to independently and reasonably evaluate possible different opinions on possible issues. COMMUNICATION SKILLS: At the end of the course, the student must have reached an appropriate organization of one's own thinking concerning the various subjects of the course, allowing her/him to expose the topics in an organic and appropriate scientific language. LEARNING CAPACITIES: The student must be able to examine and understand texts and scientific material, so that they can be used in daily contexts for the profession and for the research.
|
6
|
BIO/09
|
48
|
-
|
-
|
-
|
Related or supplementary learning activities
|
ITA |
|
18449 -
Thesis
|
32
|
|
-
|
-
|
-
|
-
|
Final examination and foreign language test
|
ITA |