Degree Course: Cellular and Molecular Biology
A.Y. 2021/2022 
Conoscenza e capacità di comprensione
Le conoscenze acquisite durante l'intero percorso della Laurea magistrale sono legate a tutte le attivita formative proposte che prevedono una approfondita conoscenza nelle aree centrali della biologia cellulare e molecolare, nell'area biochimica e in quella genetica.
In particolare, gli insegnamenti del I anno faranno acquisire allo studente il rigore del metodo scientifico sperimentale e le capacita di ragionamento logico deduttivo.
Inoltre, durante il II anno, saranno acquisite conoscenze approfondite in aree piu specialistiche della biologia, con riferimento a meccanismi molecolari per la comprensione del funzionamento degli organismi viventi e di tecnologie emergenti per la interpretazione di fenomeni biologici.
Queste conoscenze e capacita consentono agli studenti di elaborare e applicare idee originali, anche in un contesto di ricerca, con specifico riferimento alle basi molecolari e cellulari di funzionamento degli organismi.
Le conoscenze sono acquisite dagli studenti durante le lezioni in aula, con attivita pratiche in laboratorio e in campo, con visite guidate presso differenti strutture (Centri Studio, Riserve naturali, Musei, Orti botanici, Industrie e altre) con l'obiettivo specifico di avvicinare gli studenti piu facilmente al contesto lavorativo.
I docenti guideranno gli studenti nello studio proponendo e spiegando in aula gli argomenti piu rilevanti e favorendo i collegamenti interdisciplinari, nell'ottica di una conoscenza e comprensione integrata della biologia nei suoi aspetti molecolari, cellulari e degli organi.
Approfondimenti a carattere seminariale su temi specifici, con esperti esterni o proposti dagli studenti stessi a partire dall'analisi della letteratura internazionale tecnico-scientifica, amplieranno il quadro di conoscenze sviluppato dalla classe in un ambiente collaborativo e dinamico.
Le attivita di laboratorio, serviranno a far conoscere gli strumenti utilizzati per l'analisi dei sistemi biologici al fine di una loro corretta gestione e valorizzazione.
Le visite in esterno condotte con la guida di un docente, serviranno a far confrontare gli studenti con gli esperti di settore al fine di comprendere in una dimensione applicativa le conoscenze acquisite con lo studio.
La verifica del raggiungimento dei risultati di apprendimento sara effettuata attraverso varie modalita tra cui, in genere, esami orali e scritti, prove in itinere, relazioni sulle attivita di laboratorio comprese le visite didattiche, e discussioni di articoli scientifici.
L'insieme delle attivita didattiche teorico-pratiche fornisce allo studente la possibilita di accrescere le proprie conoscenze e di sviluppare la propria capacita di comprensione.
Capacità di applicare conoscenza e comprensione
Sulla base delle conoscenze acquisite durante il percorso di studio i laureati magistrali sapranno tradurre sul piano pratico le conoscenze teoriche avendo acquisito capacita critiche e metodologiche per la risoluzione di specifici problemi biologici.
In particolare, una volta acquisiti il rigore del metodo scientifico sperimentale e le capacita di ragionamento logico-deduttivo, lo studente potra affrontare e risolvere qualunque nuovo problema inerente la propria professionalita (problem solving attitude).
Inoltre, attraverso attivita pratiche, i laureati avranno acquisito la capacita di utilizzare numerose tecniche di laboratorio e di tradurre sul piano applicativo le conoscenze teoriche.
La capacita di applicare conoscenza e comprensione e raggiunta dagli studenti grazie alle esercitazioni di laboratorio e alle attivita pratiche collegate.
Questi obiettivi possono essere conseguiti mediante lo svolgimento di esercitazioni individuali in cui ogni studente e in grado di verificare le conoscenze acquisite, comprendendone l'applicazione tramite protocolli di laboratorio, sotto la supervisione del docente e di esercitatori che vengono affiancati al docente nel caso di numerosita elevata.
Le verifiche delle attivita di laboratorio possono essere attuate oralmente o mediante la valutazione di relazioni scritte sui protocolli sperimentali ed i risultati ottenuti dal singolo studente.
La capacita di applicare le conoscenze acquisite con la frequentazione delle attivita didattiche disciplinari, sara verificata anche durante la preparazione della tesi di laurea.
Autonomia di giudizio
Il laureato magistrale in Biologia Cellulare e Molecolare avra acquisito padronanza nell'analisi dei fenomeni biologici complessi.
Tale obiettivo potra essere raggiunto integrando le attivita in aula con attivita di ricerca bibliografica che potranno essere di supporto per la migliore comprensione di quanto appreso durante le lezioni frontali.
In particolare, alcuni insegnamenti presentano anche un impatto progettuale mirato all?individuazione di nuove prospettive e prevedono alcuni gradi di liberta nella progettazione di nuove esperienze di laboratorio.
Il laureato magistrale acquisira autonomia nella: (i) programmazione e conduzione di esperimenti, compresa la progettazione dei tempi e modalita di valutazione dei risultati; (ii) formulazione di problemi scientifici e capacita di proporre idee e soluzioni; (iii) capacita di reperire e vagliare fonti di informazioni bibliografiche.
L'acquisizione di autonomia di giudizio sara stimolata in tutte le unita didattiche attraverso la valutazione, interpretazione e rielaborazione di dati di letteratura, o tramite la proposizione di attivita seminariali organizzate dal Dipartimento o dall'Ateneo.
La verifica di questo apprendimento sara operata in occasione delle prove in itinere, degli esami al termine delle attivita formative e della prova finale.
Abilità comunicative
Il laureato in Biologia Cellulare e Molecolare avra acquisito adeguate competenze e strumenti per la comunicazione, anche con sistemi multimediali, del pensiero scientifico; inoltre, durante lo svolgimento della tesi di laurea magistrale gli studenti acquisiscono la capacita di elaborare e presentare progetti di ricerca, nonche di illustrare i risultati della ricerca.
Il laureato magistrale possiede le seguenti abilita:
- trasmissione e divulgazione ad alto livello dei risultati delle proprie ricerche;
- capacita di condurre il lavoro in ampia autonomia;
- interazione comunicativa in un contesto lavorativo, acquisita prevalentemente attraverso l'attivita di tirocinio;
- propensione al lavoro di gruppo e alla condivisione dei risultati.
Queste abilita verranno conseguite attraverso: (i) la stimolazione da parte dei docenti ad un dialogo durante le lezioni frontali; (ii) utilizzo di seminari specialistici con docenti ed esperti italiani e/o stranieri; (iii) strumenti offerti dal web.
Le abilita comunicative saranno verificate in occasione delle prove di verifica in itinere, degli esami al termine delle attivita formative e della prova finale.
Capacità di apprendimento
I laureati magistrali in Biologia Cellulare e Molecolare avranno acquisito capacita di studio e di apprendimento auto-diretto ed autonomo, non solo in riferimento alle conoscenze tradizionali, ma anche con strumenti tecnologici avanzati.
Infatti, essi avranno l'opportunita di consultare banche dati specialistiche, di apprendere tecnologie innovative e di acquisire strumenti conoscitivi avanzati per l'aggiornamento continuo delle conoscenze.
Queste capacita saranno realizzate sia nella creazione di programmi di insegnamenti in cui tali obiettivi vengono affrontati e sviluppati, ma anche durante lo svolgimento della prova finale.
Le capacita di apprendimento saranno verificate in occasione delle prove in itinere, degli esami al termine delle attivita formative e della prova finale.
Requisiti di ammissione
Per essere ammessi al Corso di Laurea magistrale in Biologia Cellulare e Molecolare occorre essere in possesso di diploma di laurea di primo livello nella classe L-13.
Per i laureati di altre classi, e richiesto il conseguimento di almeno 28 CFU complessivi nei settori scientifico-disciplinari indicati come caratterizzanti nell?ordinamento del CdL (BIO/06, BIO/10, BIO/11, BIO/18), avendo acquisito crediti in tutti i settori o in settori ad essi affini.
Per perfezionare l'iscrizione dovranno essere colmate le eventuali carenze formative rispetto ai requisiti curriculari.
L'ammissione e altresi subordinata all'accertamento dell'adeguata preparazione personale che verra effettuato mediante un colloquio di valutazione svolto dalla Commissione Didattica del CdS.
Il calendario dei colloqui viene pubblicato annualmente sul sito web di Dipartimento.Prova finale
La prova finale prevede un periodo di attivita di ricerca da svolgersi presso i laboratori afferenti al Corso di Laurea magistrale o in altre strutture interne o esterne al Dipartimento di Scienze Ecologiche e Biologiche.
Durante il lavoro sperimentale, lo studente acquisira conoscenze sulle metodologie sperimentali e sul metodo di indagine scientifico, nonche di analisi ed elaborazione dei dati.
Per la tipologia del percorso formativo e della figura professionale formata, l'originalita della tesi deve essere intesa come risultato di una attivita sperimentale.
Nel corso del lavoro di preparazione, lo studente dovra anche svolgere lavoro di ricerca bibliografica sull'argomento, nei testi scientifici e su riviste specializzate.
L'elaborato originale finale verra predisposto sotto la guida di un docente Relatore e verra discusso di fronte ad una Commissione di Laurea con le modalita previste dal Regolamento Didattico del CdS.Orientamento in ingresso
Le attivita di orientamento e tutorato sono svolte, previo opportuno coordinamento con il Presidente del CdS, da docenti delegati, da studenti dei corsi di laurea magistrale e del dottorato di ricerca e/o da figure qualificate opportunamente selezionate.
Durante le attivita di orientamento in ingresso rivolte agli studenti delle Scuole di Istruzione Secondaria Superiore, ci si propone di far conoscere anche i CdL magistrali incardinati presso il Dipartimento di modo da rendere chiara fin da subito la filiera didattica nelle scienze della vita agli studenti che si trovano in prossimita della scelta del corso di laurea post-diploma.
In allegato e riportata in dettaglio l'attivita di orientamento svolta relativamente ai CdL del DEB nel periodo compreso fra Maggio 2019 e Maggio 2020.
Inoltre, per gli studenti del primo anno-immatricolati al CdL in Biologia Cellulare e Molecolare, e organizzata una giornata di presentazione dei singoli corsi di insegnamento e delle attivita di ricerca che si svolgono a latere degli stessi.
I docenti, quindi, oltre ad illustrare gli argomenti che verranno trattati all'interno del proprio insegnamento, presentano le loro linee di ricerca di punta e le collaborazioni di ricerca in essere, sia esterne che interne all'Ateneo, fornendo una panoramica di possibili sbocchi futuri.
Questa giornata di presentazione ha anche lo scopo di orientare i discenti nella scelta dei possibili laboratori dove svolgere il periodo di lavoro sperimentale necessario alla preparazione della tesi di Laurea.
Il Corso di Studio in breve
Obiettivi principali del corso di Laurea Magistrale in Biologia Cellulare e Molecolare (LM-6) sono: (i) accrescere la preparazione culturale e le conoscenze nel campo della biologia di base e applicata in ambito cellulare e biomolecolare, conseguita attraverso un'approfondita preparazione scientifica, anche operativa, nelle discipline che caratterizzano il corso; (ii) dare agli studenti la possibilita di acquisire strumenti culturali specifici e metodologie di analisi.
A questo scopo, tutti i laboratori scientifici di cui si avvale il Corso di Studio (CdS) sono in grado di fornire le necessarie competenze in quanto le linee di ricerca dei docenti del CdS sono coerenti con il profilo culturale del Corso.
Il Corso di Laurea e organizzato in 2 anni che danno luogo a 120 CFU (Crediti Formativi Universitari) finali necessari per il conseguimento della laurea.
CONOSCENZE E COMPETENZE
Il laureato magistrale in Biologia Cellulare e Molecolare acquisisce conoscenze approfondite in campo biomolecolare e biomedico; inoltre matura una comprensione integrata dei fenomeni biologici a livello morfologico-funzionale, chimico/biochimico/biofisico, cellulare/molecolare con riferimento anche a meccanismi di sviluppo e dell'ereditarieta.
Al termine del percorso, i laureati avranno:
- un'ottima conoscenza aggiornata delle problematiche biologiche e delle metodologie sperimentali che sono adottate nella ricerca moderna nei campi molecolare e cellulare, al fine di sapere individuare i sistemi biologici e le metodologie sperimentali piu adeguate per lo studio di specifici fenomeni;
- competenze ad ampio spettro sulla biologia dei sistemi viventi considerando sia gli aspetti della ricerca di base, sia le potenziali applicazioni bio-tecnologiche;
- padronanza del metodo scientifico e capacita di analizzare i dati sperimentali;
- capacita di lavorare in gruppo con autonomia e responsabilita.
SBOCCHI PROFESSIONALI
I laureati della classe potranno svolgere: (i) attivita di ricerca di base e applicata in campo biologico, biomedico, biologico-molecolare, nutrizionistico, fisiologico e genetico in istituti di ricerca pubblici o privati e nelle Universita; (ii) attivita professionali e di progetto in ambiti correlati con le discipline biologiche, negli istituti e nei settori dell'industria, della sanita e della pubblica amministrazione; (iii) attivita libero-professionali ed imprenditoriali nell'ambito delle Scienze della vita in qualita di biologi ed assimilati; (iv) attivita di gestione di laboratori di analisi cliniche, biologiche e microbiologiche, di controllo biologico e di qualita dei prodotti di origine biologica e delle filiere produttive; (v) attivita di promozione e innovazione scientifica e tecnologica nei vari settori della biologia, nonche di gestione e progettazione delle tecnologie.
Il laureato potra altresi avere accesso a svariati corsi di Dottorato di ricerca e diverse scuole di specializzazione.
Il laureato magistrale in Biologia Cellulare e Molecolare potra iscriversi (previo superamento del relativo esame di stato) all'Albo per la professione di biologo sezione A, con il titolo professionale di Biologo Senior, per lo svolgimento delle attivita codificate.
Lo studente espliciterà le proprie scelte al momento della presentazione,
tramite il sistema informativo di ateneo, del piano di completamento o del piano di studio individuale,
secondo quanto stabilito dal regolamento didattico del corso di studio.
Percorso STANDARD
FIRST YEAR
First semester
|
Course
|
Credits
|
Scientific Disciplinary Sector Code
|
Contact Hours
|
Exercise Hours
|
Laboratory Hours
|
Personal Study Hours
|
Type of Activity
|
Language
|
|
14800 -
BIOCHIMICA CELLULARE
(objectives)
The course envisages the deepening of two themes of considerable scientific interest:
1) Protein engineering techniques that allow design, expression and purification of recombinant proteins in heterologous systems;
2) Deepening the biochemical and molecular mechanisms of cell cycle control in eukaryotes.
EXPECTED LEARNING OUTCOMES
Knowledge and
understanding:
At the end of the training activities students will have in-depth knowledge of the biochemical and molecular basics of cell cycle control in eukaryotes. They will also learn the main techniques for the design and expression of recombinant proteins in heterologous systems. In general, they will have developed the ability to understand the pivotal experimental approaches for acquiring knowledge.
Applying knowledge
and understanding:
During the course, students will be encouraged to use the knowledge acquired for their application to specific problems, such as the design of new, more potent and / or more selective proteins for their use in various fields of interest (biomedical, agro-food, etc.).
Making judgements:
Students will be able to interpret and discuss the scientific papers presented during the course and be able to design and express new proteins with different characteristics.
Communication skills:
During the lessons students will be stimulated to discuss and compare different point of views in order to develop their communicative abilities that will be verified during the preliminary and final examinations at the end of training activities.
Learning skills:
Students will be able to describe scientific topics related to the course. This skill will be developed through the active involvement of students through oral class discussions and practical experiences during the hours dedicated to the experimental laboratory.
|
6
|
BIO/10
|
40
|
-
|
8
|
-
|
Core compulsory activities
|
ITA |
|
14890 -
CITOGENETICA
(objectives)
LEARNING OBJECTIVES
The course introduces the fundamental concepts and experimental approaches to the study of cytogenetics, a branch of genetics that analyzes the structure of the chromosomes to determine the relationship existing between the hereditary and specific karyotypes characters.
The course aims to consolidate and expand the knowledge base on chromatin structure and its intranuclear organization, the metaphase chromosome as well as its specialized structures such as centromere, telomere and fragile sites and their role in maintaining genome stability. The course also aims to address the study of human chromosomal instability syndromes and the role of the biologist in their diagnosis using classical and molecular cytogenetics techniques.
It also provides a basis for specialized studies such as the analysis of chromosomal aberrations in biological dosimetry and the use of the Comet test in genotoxicity. In particular, these issues are provided in the laboratory practice.
|
6
|
BIO/18
|
40
|
-
|
8
|
-
|
Core compulsory activities
|
ITA |
|
13688 -
GENETICA DELLO SVILUPPO E EPIGENETICA
(objectives)
The course will introduce students to the principles, experimental approaches and potentialities of the genetic analysis of animal development, with particular regard to that of Drosophila melanogaster; the panorama of epigenetic phenomena will be presented and the molecular mechanisms underlying the phenomena of epigenetic inheritance will be investigated; "genome wide" epigenetic analyzes and epigenomic synthesis will be addressed.
Students will have to know how to apply the notions learned to the resolution of the questions that emerge from the analysis of development and epigenetic phenomena in complex organisms.
Students will have to develop the ability to identify and address aspects related to development and epigenetics in the analysis of complex processes.
They will also have to be able to learn independently by doing bibliographic research on the topics covered and communicate the results of their research.
|
6
|
BIO/18
|
48
|
-
|
-
|
-
|
Core compulsory activities
|
ITA |
|
17461 -
PROTEOMICA E METABOLOMICA
(objectives)
FORMATIVE OBJECTIVES
The course provides the theoretical bases of proteomics, interatomics and matabolomics as relevant scientific disciplines able to provide useful structural and dynamic information about the proteoma and metaboloma. The course will introduce students to the principles and the experimental approaches, and the learning objectives will be achieved by presenting students with the state of innovation in the specific field with a substantial presence in the laboratories. Particular attention will be given to the study of mass spectrometry techniques for the identification of proteins, metabolites and alterations of protein expression, thus enabling them to shed light on the biological complexity of a tissue in order to differentiate / identify a pathological state from the physiological one.
b) EXPECTED LEARNING RESULTS
1) Knowledge and understanding
The student will develop the knowledge of the principles of proteomics and metabolomics. Indispensable for experimental analysis and interpretation of results in biochemical and molecular biological disciplines.
2) Applyng knowledge and understanding.
The student will also be introduced to the knowledge of the major classes of small biological molecules and metabolites and will learn the basic metabolic pathways through which these molecules are degraded and synthesized. It will be familiar with the main separation methods (2Dgel, HPLC) and will use instrumentation for the identification of high performance proteins and metabolites such as MALDI TOF / TOF, ESI-TRAP.
3) Making judgments
Students will be able to independently carry out observations and experiments in the field of Proteomics or metabolomics. They will also have critical thinking and evaluation skills to rationalize them in an interpretative model.
4) Communicative skills.
Students will be able to work in groups and communicate clearly their knowledge
Or the results of your research,
5) Learning skills
Students will need to learn autonomously by using advanced texts in Italian and English.
English texts will be provided during the year. Students also be able to perform bibliographic research even at advanced level, selecting relevant topics; of proteomics and metabolomics
|
6
|
BIO/11
|
32
|
16
|
-
|
-
|
Core compulsory activities
|
ITA |
Second semester
|
Course
|
Credits
|
Scientific Disciplinary Sector Code
|
Contact Hours
|
Exercise Hours
|
Laboratory Hours
|
Personal Study Hours
|
Type of Activity
|
Language
|
|
13700 -
DIETETICA E ALIMENTI FUNZIONALI
(objectives)
Educational objectives
The aim of the course is to provide students with the information needed to understand the theoretical / practical bases of food science and, in particular, the evolution that this subject has undergone over the years. In fact it no longer deals only with satisfying the nutritional needs of the individual but tends to be a means for the prevention and treatment of some diseases. In this course then it will be about functional foods pointing out that part of the classic and modern diet and the experimental approaches that have allowed its evolution. Students will have to learn the meaning of functional foods and novel foods as well as learn which criteria and which technological approaches to use to improve food quality.
Finally, the course aims to provide the basis for further in-depth studies in the field of foods and their effect on the human organism. The topics concerning nutrigenetics and nutrigenomics will also be addressed.
Expected learning outcomes
Knowledge and understanding: To have developed the knowledge of the principles of classic food science and some dietary principles. Furthermore, the relationship between diet and health should be clear in order to bring this knowledge into the process of food transformation and improvement. Have communication skills in the field of Food Science
Ability to apply knowledge and understanding: the student should be able to use the knowledge acquired to work in the food industry and in particular in the field of functional foods.
Making judgements: Being able to improve the quality of food and to identify new ingredients for the development and food with high health properties.
Communication skills: The students' ability to talk, reason and discuss the questions raised during the lessons on the topics discussed will be stimulated.
Learning skills: Being able to discuss scientific topics concerning food science also in its bio-medical applications and its implications in the food industry. This skill will be developed and tested by involving students in oral discussions in the classroom.
|
6
|
MED/49
|
48
|
-
|
-
|
-
|
Core compulsory activities
|
ITA |
|
118999 -
BIOINFORMATICS AND APPLICATIONS
(objectives)
Aim of the course is to train students in various fields of Bioinformatics, with particular regard to the knowledge of state-of-the-art tools used to support biological research.
In detail, training objectives are:
1) Basic knowledge in Informatics/Bioinformatics
2) Biological databases: inquiry and programmatic access
3) Alignment of nucleotide and amino acid sequences
4) In silico structural and functional characterization of genes and proteins
5) Bioinformatic analysis applied to Next-Generation-Sequencing data.
EXPECTED LEARNING OUTCOMES:
KNOWLEDGE AND UNDERSTANDING. At the end of the course the students will get the following: the basic principles of bioinformatics, how biological databases are designed, managed, and queried, how sequences similarity search are performed, how to perform in silico characterization of genes and proteins and of how to analyse data from Next-Generation-Sequencing platforms.
APPLYING KNOWLEDGE AND UNDERSTANDING. Understanding the computational approaches discussed in the lessons and their applications to specific problems.
MAKING JUDGEMENTS. Be able to critically interpret the results obtained through the bioinformatics tools discussed during the course, as well as choose the ones most suitable to achieve a specific goal.
COMMUNICATION SKILLS. Students should acquire the ability to transfer the acquired knowledge in a clear and comprehensible manner, even to people who are not in the field, and must demonstrate the ability to present the acquired information.
LEARNING SKILLS. Be able to describe the topics of Bioinformatics in oral form. This ability will be developed by the active involvement of the students through class discussions and practical activities organized in the Informatics room on specific topics.
|
6
|
BIO/11
|
48
|
-
|
-
|
-
|
Core compulsory activities
|
ITA |
|
17449 -
BIOLOGIA CELLULARE E DELLO SVILUPPO
(objectives)
TRAINING OBJECTIVES
The course introduces the rapidly evolving principles and approaches to cellular biology and developmental biology. The course aims to consolidate and widen the basic knowledge of cellular functioning (how cells interact with each other and with the tissue environment, how they differentiate and how they develop in tissues and how they can regenerate the complexity of an organ). It provides a framework for understanding the several issues into currently sciences up to date (eg stem cells and cancer cells and their biomedical application potential, translational study models) and it provides the basis for further deepen studies in cellular biology and development.
• knowledge and understanding: Knowledge of cell biology principles applied to developmental biology. Knowledge of the principles of inter- and intra-cellular communication; of the molecular mechanisms of the regulation of the expression of genes related to development, differentiation, de-differentiation, migration, cell survival. Embryonic and adult stem cells, regeneration.
• applying knowledge and understanding: In addition to the knowledge acquired through the study of cell biology and development, students will understand and explore the applicative potential of the subject in the sector of organ and tissue regeneration, the control of stem and tumor cell differentiation in the field of biomedical disciplines and translational medicine.
• making judgments: The course offers connections with other disciplines of the Degree course (molecular biology, biochemistry, bioinformatics, genetics, and epigenetics) providing an integrated, current and dynamic knowledge, capable of specific insights such as 1) reading of scientific material found through keyword research and also provided and shared with learners on the google-drive website; 2) organized seminars; 3) further integration of knowledge with exams of your choice in the second year of the course. These three points represent strength for achieving an interpretation of experimental results of cell biology and development similar to those discussed in class.
• communication skills: During the lessons students are invited to give their opinion and to study in a group to develop their communication skills. These skills are then verified during the exam tests at the end of the training activities.
• learning skills: Students will be able to describe scientific topics related to cell biology and development. Such restitution skills will be developed through the active involvement of students in the in-depth study of the course topics. The learners will thus be encouraged to report in-class (also in a group) in-depth topics related to the course. The involvement of students in the improvement of the course content represents a fundamental growth point of training for the learner, but also for the teacher.
|
6
|
BIO/06
|
48
|
-
|
-
|
-
|
Core compulsory activities
|
ITA |
|
17451 -
BIOLOGIA MOLECOLARE II
(objectives)
COURSE OBJECTIVES. The course aims to provide adequate knowledge for the understanding of the biochemical and molecular mechanisms responsible for extracellular signal transduction and possible connections between these events and nuclear dynamics. In addition, the mechanisms of regulation of gene expression in some model systems (lambda bacteriophage, GAL genes in S. cerevisiae, HIV virus, human beta-interferon gene) will be thoroughly analyzed, paying attention to possible evolutionary implications. Particular emphasis will be given to the post-transcriptional regulatory strategies in which non-coding RNAs are involved.
KNOWLEDGE AND UNDERSTANDING. To acquire in-depth knowledge of protein-protein interactions (the basis of intracellular communication), and between nucleic acids and proteins (the basis of gene expression control). Owning up-to-date information on the role of catalytic and regulatory RNAs.
APPLYING KNOWLEDGE AND UNDERSTANDING. Being able to correlate the three-dimensional structure of proteins and nucleic acids with their biological functions. To possess the ability to translate the latest knowledge of molecular biology into some application areas, such as the medical one.
MAKING JUDGEMENTS. To achieve a fuller understanding of the molecular mechanisms at the basis of life, along with the ability to discuss their role. To acquire the autonomy needed to align the gained scientific knowledge with advances in biological research.
COMMUNICATION SKILLS. To demonstrate mastery of skills and knowing how to convey them adequately. To develop the ability to use the correct terminology.
LEARNING SKILLS. To be able to grasp, rework and discuss the scientific issues dealt with in the lesson, including their applications.
|
6
|
BIO/11
|
48
|
-
|
-
|
-
|
Core compulsory activities
|
ITA |
|
118993 -
STAGE
|
4
|
|
-
|
-
|
-
|
-
|
Other activities
|
ITA |
SECOND YEAR
First semester
|
Course
|
Credits
|
Scientific Disciplinary Sector Code
|
Contact Hours
|
Exercise Hours
|
Laboratory Hours
|
Personal Study Hours
|
Type of Activity
|
Language
|
|
119000 -
ENGLISH B2
(objectives)
The course, which provides an intermediate level of knowledge of the English language, is aimed at strengthening the main language structures to B2 level of the CEFR.
|
6
|
|
48
|
-
|
-
|
-
|
Other activities
|
ITA |
Optional Group:
OPZIONALI II ANNO - (show)
|
12
|
|
|
|
|
|
|
|
|
15406 -
DIAGNOSTICA STRUMENTALE, BIOFISICA E NANOSCIENZE
(objectives)
The course has the following main objectives:
• Acquire the basic knowledge of biophysics and nanosciences useful for understanding biological phenomena and applying innovative approaches to their study.
• Acquire the theoretical and experimental bases of some advanced spectroscopic and nanoscopic techniques, present at the Center for Biophysics and Nanosciences, aimed at studying the structural, dynamic and interaction properties of biological systems. Particular attention will be paid to techniques and problems related to the detection of biological and biomedical markers of diagnostic interest.
• Improve the skills necessary to carry out the experimental activity in an aware and critical way. To this end, individual exercises will be carried out by the students on biological systems of interest, making use of the biophysical-nanotechnological techniques learned in the theoretical part. The procedures followed, the data analysis and the results obtained will be discussed in order to stimulate the capacity for synthesis and criticism.
• Develop communication skills through the presentation of a recent scientific work, freely chosen, of biological interest and making use of a technique among those presented during the course.
|
6
|
FIS/07
|
24
|
-
|
24
|
-
|
Related or supplementary learning activities
|
ITA |
|
118995 -
GENETICS AND PHARMACOGENOMICS OF AGING AND ASSOCIATED DISEASES
(objectives)
GOALS
The course is aimed at providing students with the basic notions for the understanding of genetic and molecular bases of aging and longevity, the pathogenetic bases of diseases associated with aging and finally the basics of pharmacogenetics and pharmacogenomics, disciplines that aim to identify genes and gene variants that cause the inter-individual variability in drugs response.
EXPECTED RESULTS
1) Knowledge of the genetic basis of aging and longevity biology;
2) Understanding the experimental approaches of aging genetics;
3) Knowledge of drug-organism interaction (at molecular and cellular levels) that determines the efficacy or toxicity of drug treatment and the role of interindividual genetic variability (primarily genetic polymorphisms) in determining the variability of drug response;
4) Being able to apply the knowledge developed in points 1, 2 and 3 to understand specific cases;
4) Being able to express conceps with appropriate scientific terminology
5) Ability to understand and describe experiments which contributed to the understanding of the genetic basis of aging, the associated pathologies and their possible pharmacological treatment.
|
6
|
BIO/18
|
40
|
-
|
8
|
-
|
Related or supplementary learning activities
|
ITA |
|
118994 -
CHEMISTRY OF NATURAL SUBSTANCES
|
Also available in another semester or year
|
|
17467 -
TECNICHE BIOMOLECOLARI
(objectives)
a) TRAINING OBJECTIVES
The course of BIOMOLECULAR TECHNIQUES intends to provide students with theoretical and practical knowledge of the major molecular biology and biochemical techniques applied to the study of genes, genomes, proteins and proteomes. Experimental approaches will be discussed, making use also of bioinformatics, to address complex biological questions in biochemistry and molecular biology.
In detail, it is intended to provide students with specific skills for the manipulation and analysis of nucleic acids and proteins (mutagenesis and genome editing techniques, differential proteomic), for the analysis of gene expression levels (qPCR, microarrays, differential transcriptomic) and gene expression regulation (study of epigenetic modifications and protein-DNA interactions), for the study of transduction signal pathways by protein-protein interaction analysis. The advances in the field of the sequencing of whole genomes and the application of biomolecular techniques in diagnostic field will be also discussed. Bioinformatics tools will be used for in silico prediction of interaction between biomolecules, or as complementary for the use of the discussed techniques (for input or output analysis). Finally, laboratory practical experiences will be organized to acquire techniques for studying nucleic acids and proteins.
B) EXPECTED LEARNING OUTCOMES
1)Knowledge and understanding
At the end of the course the students will know the basic techniques used in the field of fundamental and applied research. They will have an in-depth knowledge of molecular and advanced techniques and the related bioinformatics tools to support them; they will know the importance of statistical validation of the results of an experiment and of the controls that make an experiment scientifically reliable.
2)Applying knowledge and understanding:
At the end of the course the students will be able to use the acquired knowledge to evaluate and interpret the results of an experiment, identify its strengths and weaknesses and optimize it by evaluating the possible impact of variations in key experimental parameters; orient themselves among the main qualitative and quantitative methods to select the most suitable ones for studying the biological problem of interest; perform the experiments carried out during the practical part of the course.
3)Making judgements
Students will be able to interpret and discuss the scientific papers presented during the course and be able to design and express new proteins with different characteristics. Students will have to acquire the ability to understand and critically discuss the experimental results obtained in the laboratory and use them as a starting point for planning subsequent experiments.
4)Communication skills
Students should have the ability to convey the acquired knowledge in a clear and comprehensible manner, even to people who are not in the field, and must demonstrate the ability to present information also with schemes and formulas.
5)Learning skills
Students will have to be able to describe scientific topics related to the course. This skill will be developed through the active involvement of students during class discussions and practical experiences during the hours dedicated to the experimental laboratory.
|
6
|
BIO/10
|
32
|
-
|
16
|
-
|
Related or supplementary learning activities
|
ITA |
|
15407 -
MICOLOGIA GENERALE E FILOGENESI
|
Also available in another semester or year
|
|
Second semester
|
Course
|
Credits
|
Scientific Disciplinary Sector Code
|
Contact Hours
|
Exercise Hours
|
Laboratory Hours
|
Personal Study Hours
|
Type of Activity
|
Language
|
|
Optional Group:
OPZIONALI II ANNO - (show)
|
12
|
|
|
|
|
|
|
|
|
15406 -
DIAGNOSTICA STRUMENTALE, BIOFISICA E NANOSCIENZE
|
Also available in another semester or year
|
|
118995 -
GENETICS AND PHARMACOGENOMICS OF AGING AND ASSOCIATED DISEASES
|
Also available in another semester or year
|
|
118994 -
CHEMISTRY OF NATURAL SUBSTANCES
(objectives)
A) OBJECTIVES
The course introduces the concepts and experimental approaches to the chemistry of bioactive substances by consolidating the principles gained under the organic chemistry course, focusing on biogenesis, synthesis, chemical structure and pharmacological properties of bioactive substances . In the first part of the course, the concept of the "pharmacophore theory" will be introduced as a minimal structural unit characterized by a specific biological and clinical activity. Bioactive substances, both of synthetic and natural origin, will be classified according to their main pharmacophores. The student will learn to recognize the pharmacophore even in the context of complex molecular structures. In the second part of the course, critical tools will be provided to associate certain pharmacophorees to specific pharmaceutical and pharmacological applications, with particular attention to the molecular action mechanism by with which the bioactive substances act in the body. The student will be able to understand the natural origin of bioactive organic substances and their possible industrial applications by receiving specific training on the design, development and evaluation of new drugs. In addition, due to the knowledge of molecular action mechanisms, the student may associate the use of bioactive substances with specific nutraceutical, cosmeceutic and cosmetic products, including restrictions on the use of potentially toxic substances and the possibility of their use after functional and structural improvement. This knowledge will enable the student to deal with a professional career within the pharmaceutical, nutraceutical and cosmeceutical industry.
B) EXPECTED LEARNING RESULTS
• Knowledge and understanding: Knowledge of the principles that define the minimum structural unit of an organic, natural or synthetic molecule, to have a certain biological activity (pharmacophore theory). Knowledge of the relationship between the type of pharmacophore present in an organic molecule and the pharmaceutical and pharmacological activity. Knowledge ot the molecular-level of the action mechanism of the major families of bioactive substances, with particular attention to substances with antioxidant, antiviral, anti-inflammatory and antitumour activity. Knowledge of the key steps for the design of a drug, and procedures for its clinical validation and use. Knowledge of the origin and distribution in nature of the main families of biologically active natural organic substances.
• Applied knowledge and understanding: In addition to the knowledge gained through the bioactive substance chemistry study, students will be able to apply theoretical concepts acquired during the course in solving practical exercises based on the teacher's request to present possible schemes for the design of a drug, having the initial indication of the target of action at the molecular level and knowing the type of pathology against which the treatment therapy is to be developed. In this case, students will also have to apply their previous knowledge of chemistry and biology for complete resolution of the problem.
• Making judgements: At the end of the course, the student will have acquired the necessary training for full autonomy of judgment on the possibility of using a certain organic substance of natural or synthetic origin for the therapy of a certain pathology . The student will then be able to link the acquired knowledge of biochemistry, molecular biology, enzymology, physiology and genetic to the design of a substance applicable in the pharmaceutical, nutraceutical and cosmeceutical fields.
• Communication skills: students will be continuously and consistently invited to participate actively in the lesson in order to deepen the topic and to collect proposals for possible solutions in the case of complex phatological scenarios. In this activity, students will be called upon to meet in order to support their ideas. The educational pitch is aimed at increasing the communicative skills and the ability to know how to work and to confront a group, all aimed at consolidating the acquired concepts.
• Learning Skills: Students' learning abilities will be evaluated during the course of the course by tests that will allow to individually monitor the maturation state of the knowledge, highlighting the student's ability to return the aquired cencepts.
|
6
|
CHIM/06
|
48
|
-
|
-
|
-
|
Related or supplementary learning activities
|
ITA |
|
17467 -
TECNICHE BIOMOLECOLARI
|
Also available in another semester or year
|
|
15407 -
MICOLOGIA GENERALE E FILOGENESI
(objectives)
The aim of the course is to provide students with the information needed to understand the biology and diversity of the Fungal Kingdom, which remains one of the main gaps in a biologist's knowledge. Understanding the importance of these organisms in maintaining the balance of any ecosystem, the importance of their interaction with all the other compartments of the biota. The strategies of adaptation to the environment, of the mechanisms of reproduction at the base of their conservation. This knowledge is an indispensable requisite for understanding their role on ecosystem and maintaining their balance even in view of the risks associated to Global Change.
Expected learning outcomes:
1) Knowledge and understanding. To have developed the knowledge of the biodiversity of these organisms and their morphological and physiological characteristics, resulting from adaptation to specific and different environmental conditions.
2) Ability to apply knowledge and understanding. Knowing how to use the concepts learned in class and developed in the exercises to interpret any morpho-functional alterations due to changes in environmental parameters.
3) Ability to elaborate molecular data ad build up the workflow for a phylogenetic analysis.
3) Autonomy of judgment. Ability to formulate hypotheses in response to possible problems.
4) Communication skills. The acquisition by the students of a scientifically correct terminology related to the topics will be stimulated.
5) Learning skills. Stimulate curiosity and knowledge on the world of Fungi.
|
6
|
BIO/03
|
24
|
-
|
24
|
-
|
Related or supplementary learning activities
|
ITA |
|
|
- -
ELECTIVE COURSE
|
12
|
|
96
|
-
|
-
|
-
|
Elective activities
|
ITA |
|
118996 -
FINAL TEST
|
38
|
|
-
|
-
|
-
|
-
|
Final examination and foreign language test
|
ITA |
