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Teacher
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PESSINA Gloria
(syllabus)
History of Human Identification. The Birth of Forensic Genetics: History, Discoveries, and Applications. Biology: Eukaryotic Cell Organization: Organelles and Functions. DNA: Structure and Characteristics. Genes and the Genetic Code. Human Genome Organization. The Cell Cycle. DNA Replication. Mitosis and Meiosis. Gametogenesis and Fertilization. Alleles. RNA: mRNA, tRNA, and rRNA. Protein Synthesis Mitochondrial DNA Genotype/Phenotype Mendel's Laws The Concept of Multifactoriality Genetic Variants: Mutations Polymorphisms: CNVs, SNPs, and VNTRs VNTRs: Satellite DNA, Minisatellites, and Microsatellites (STRs) The Concept of Genetic Markers STRs: Characteristics, Forensic Use, Nomenclature The Phases of the Forensic Investigation: The Judicial Investigation: Research, Collection, Preservation, and Transport of Traces and Types of Biological Traces General and Species Diagnosis DNA Extraction DNA Quantification Individual Diagnosis: Creation of a Genetic Profile, DNA Amplification (PCR) Data Disclosure Capillary Electrophoresis and Data Interpretation Loci used (CODIS, ESS, Amelogenin) Biological artifacts and technical issues Statistical analysis, comparison, and statistical weighting of evidence Paternity and kinship testing Descent markers Y chromosome: characteristics, haplotypes, and haplogroups Mitochondrial DNA: characteristics, haplotypes, and haplogroups Difficult specimens National DNA databases: regulations and applications New frontiers in forensic genetics
(reference books)
Adriano Tagliabracci, Introduzione alla GENETICA FORENSE. Indagini di identificazione personale e di identità, Ed. Springer (2010); Dispense del docente
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