Derived from
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15291 GENETICA in Biological Sciences L-13 0 PROIETTI DE SANTIS Luca
(syllabus)
Mendel's genetic analysis: genetic variability; the law of segregation; the law of independent assortment; genes and alleles: the concept of polymorphism.
Extensions of Mendelian analysis: dominance relationships; multiple allelia; pleiotropy; multifactorial inheritance, inheritance of quantitative traits ..
Chromosome theory of inheritance: mitosis and meiosis; sex-linked inheritance; meiosis and Mendelism.
Association and recombination: segregation of genes located on the same chromosome; crossing over-over; the chi-squared test genetic maps; three-point essay.
The physical basis of heredity, DNA: identification of the genetic material; structure; * replication; * recombination.
The function of the gene: genetic dissection through mutations the hypothesis a gene an enzyme; complementation; fine structure of the gene; the genetic code; the transcription; * translation. *
The eukaryotic chromosome structure and organization of chromatin; the model with radial lugs; structure and function of the telomere and centromere; the organizing regions of the nucleolus (NOR).
Chromosomal mutations: of structure; the mobile elements; of number.
Genetic analysis of bacteria and viruses *: the bacterial chromosome; isolation of mutants; gene transfer in bacteria: natural and artificial transformation; conjugation; genetic maps in bacteria. transduction
Gene regulation in prokaryotes: negative and positive regulation; the lac operon; the tryptophan operon; attenuation.
Gene regulation in eukaryotes: regulation of transcription; post-transcriptional regulation; the role of chromatin structure; epigenetic inheritance; euchromatin and heterochromatin; variegated position effect (PEV); inactivation of the X chromosome in mammals.
Genomic analysis: the cloning of genes; hybridization of nucleic acids; the PCR; DNA sequencing; genome sequencing; DNA polymorphism analysis: SNP; Microsatellites.
Population genetics: gene and genotype frequencies the Hardy-Weinberg equilibrium; evolution of populations and species.
* These topics are treated only from the point of view of Genetics, leaving out the biochemical, molecular and microbiological aspects that are treated in other courses.
(reference books)
Griffiths et al., Genetica - Principi di analisi formale, Zanichelli
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