Farmacogenetica
(objectives)
GOALS The course is aimed at providing students with the basic notions for the understanding of genetic and molecular bases of aging and longevity, the pathogenetic bases of diseases associated with aging and finally the basics of pharmacogenetics and pharmacogenomics, disciplines that aim to identify genes and gene variants that cause the inter-individual variability in drugs response.
EXPECTED RESULTS 1) Knowledge of the genetic basis of aging and longevity biology; 2) Understanding the experimental approaches of aging genetics; 3) Knowledge of drug-organism interaction (at molecular and cellular levels) that determines the efficacy or toxicity of drug treatment and the role of interindividual genetic variability (primarily genetic polymorphisms) in determining the variability of drug response; 4) Being able to apply the knowledge developed in points 1, 2 and 3 to understand specific cases; 4) Being able to express conceps with appropriate scientific terminology 5) Ability to understand and describe experiments which contributed to the understanding of the genetic basis of aging, the associated pathologies and their possible pharmacological treatment.
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