| FUNDAMENTALS OF CHEMISTRY FOR DESIGN
(objectives)
The course introduces the concepts and experimental approaches of organic chemistry, consolidating the principles acquired in physics and general and inorganic chemistry courses to proceed with the knowledge of carbon chemistry. In the first part of the course, the cultural and practical bases for understanding the structure of organic molecules will be provided, paying particular attention to the relationships existing between the chemical structure and the chemical-physical and biological properties associated with them. The different physical hybridization states of carbon will allow the three-dimensional view of the molecules, facilitating the understanding of their role in the cell. The second part of the course is dedicated to the application of properties in the context of chemical reactivity. The student will have the opportunity to have the answers to some of the fundamental questions in his studies: why do molecules react? What are the experimental factors that control the kinetics of reactions? When is a reaction under thermodynamic rather than kinetic control? How is it possible to synthesize complex molecules starting from simple reagents? What is the impact of organic chemistry on the environment and how can it be reduced? This knowledge will allow the student to face subsequent study courses with strong structural and molecular competence.
EXPECTED LEARNING OUTCOMES • Knowledge and understanding: Knowledge of the principles that regulate the formation of chemical bonds, through the use of traditional theories (valence bond theory) and advanced theories (molecular orbital theory and hints of quantum mechanics ). Knowledge of the nomencleture and classification (functional group theory) of organic molecules, with particular attention to the association between the family of organic molecules and biological and chemical-physical properties. Knowledge of the reactivity of organic molecules and of the experimental parameters capable of controlling the thermodynamics and kinetics of organic transformations. Knowledge of the relationship between organic molecules and the origin of life. • Applying knowledge and understanding: In addition to the knowledge acquired through the study of organic chemistry, students will be able to apply the concepts acquired to solve practical exercises relating to the identification and classification of substances based on their activity on the organism, the effect of chirality on pharmacological activity, the possibility of separating isomeric organic substances and the general methodologies for their analysis and recognition. • Making judgments: The course offers connections with other disciplines of the degree program (physics, general chemistry, biochemistry, molecular biology, computational chemistry and genetics) providing integrated knowledge. The student's critical judgment will be stimulated by continuously referring to the reading of recent studies published in scientific journals in the sector, questioning the current problems relating to some of the fundamental concepts of the discipline. Thanks to the multi- and interdisciplinary nature of organic science, it will also be possible to connect the notions acquired to the problems of other disciplines, allowing the student to form his own independent judgment regarding the effectiveness of an integrated scientific approach. • Communication skills: At the end of each essential part of the course, students will be invited to form working groups to develop solutions and compete with others in solving practical exercises. The teaching tool is aimed at increasing communication skills and the ability to know how to work in a group, all aimed at consolidating the concepts acquired. • Ability to learn (learning skills): The students' learning abilities will be assessed during the course through exemption tests which will allow the state of maturation of knowledge to be followed individually, highlighting the student's ability to repay.
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Teacher
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SALADINO Raffaele
(syllabus)
Module A STRUCTURE Alkanes and cycloalkanes. Introduction. Structure. Sp3 hybridization. Nomenclature. Physical Properties. Isomerism of structure. Conformational analysis (ethane, cyclohexane). Stability of cycloalkanes (angle strain, torsional strain, tension steric). Derivatives of cyclohexane (stereoisomery cis-trans). Bicyclic alkanes and polycyclic. Natural role and applications of alkanes.
Alkenes. Introduction .. Structure. Sp2 hybridization. Nomenclature. Physical Properties. Stability (heat of hydrogenation, heat of combustion). Nomenclature system (E) - (Z) for alkenes. Cicloalcheni.Funzione biological.
Alkynes. Introduction. Structure. Sp hybridization. Nomenclature. Physical Properties.
Functional groups and classes of organic compounds. Alkyl halides. Alcohols. Ethers. Amines. Aldehydes and ketones. Carboxylic acids. Esters and amides. Introduction. Structure. Nomenclature. Physical Properties.
Stereochemistry. Introduction. Chirality of carbon. Enantiomers and chiral molecules. Graphical representation. Nomenclature (R) (S). Optical activity (specific optical rotation, definition of racemate, optical purity). Diastereoisomers (meso compounds). Chiral molecules without chiral carbons.
Aromatic compounds. Introduction. Benzene. Structure and stability. Huckel rule. Other aromatic compounds. Nomenclature of benzene derivatives. Induction phenomena and resonance. Heterocyclic aromatic compounds. The aromatic compounds in biochemistry.
Carbohydrates. Classification. Monosaccharides. Mutarotation and formation of glucosides. Configuration D or L. Disaccharides. Polysaccharides.
Protein. Structure of the amino acids. Nomenclature. Peptide bond. Oligopeptides.
Nucleic acids. Purine and pyrimidine nucleic bases. Nucleosides. Nucleotides. Oligonucleotides.
Lipids.
Form B. THE REACTIVITY '
Reactions of alkanes and cycloalkanes. Chlorination of methane. Free radicals. Stability and structure. Thermodynamics and kinetics. Halogenation of higher alkanes.
Ionic reactions of substitution and elimination. Formation of carbocations. Stability and structure. Nucleophilic substitution reactions. SN2 re
(reference books)
- Chimica Organica Essenziale, Bruno Botta, Editore EdiTes (edizione più recente). Da consultare: - Chimica Organica, Robert Thornton Morrison, Robert Nielson Boyd, Casa Editrice Ambrosiana. Distribuzione Zanichelli (edizione più recente).
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Dates of beginning and end of teaching activities
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From to |
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Delivery mode
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Traditional
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Attendance
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not mandatory
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Evaluation methods
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Oral exam
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