Teacher
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BERNINI Roberta
(syllabus)
The course is divided into two parts. The first includes lectures; the second, includes exercises, seminars, laboratory activities. Introduction to the course. Description of the program, of the training objectives and of the expected results. Description of the examination method and evaluation criteria. Presentation of the international Scopus and Web Science databases. Chemical structure, biological properties and applications in the agronomic, food, cosmetic, pharmaceutical and nutraceutical fields of the main natural organic substances (secondary metabolites) present in the plant world described by following the biogenetic pathways. Metabolites derived from the acetate pathway. Saturated fatty acids. Unsaturated fatty acids. Uncommon (acetylenic and branched-chain) fatty acids. Prostaglandins. Thromboxanes. Leukotrienes. Macrolides. Statins. Simple phenols. Tetracyclines. Anthraquinones. Antrones. Diantrones. Anarcardic acids. Urusciols. Aflatoxins. Cannabinoids. Metabolites derived from the shikimate pathway. Aromatic amino acids. Benzoic acids. Cinnamic acids. Lignans. Lignin. Phenylpropanes. Coumarins. Stilbenes. Flavonoids. Flavonolignans. Isoflavonoids. Benzoquinones. Naphthoquinones. Anthraquinones. Terpenoid quinones. Hydrolyzable tannins. Condensed tannins. Metabolites derived from the mevalonate pathway. Hemiterpenes. Linear, cyclic and irregular monoterpenes. Iridoids. Secoiridoids. Sesquiterpenes. Diterpenes. Sesterterpenes. Triterpenes. Tetraterpenes. Higher terpenoids. Steroids. Alkaloids derived from ornithine, lysine, nicotinic acid, tyrosine, tryptophan, anthranilic acid, histidine, amination reactions; purine alkaloids. Free radicals. Oxidative stress. Antioxidants. In vitro methods for determining antioxidant activity. Traditional and innovative extraction techniques of natural substances. Techniques of separation and characterization of natural substances. Chromatographic techniques. Nuclear Magnetic Resonance.
(reference books)
For a good exam preparation, the following textbook is recommended: “Medicinal Natural Product. A Biosynthetic Approach” - Paul M. Dewick. John Wiley Sons, Ltd On the Moodle platform, on the course page, the slides of all the lessons held by the teacher are available
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