Teacher
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ROMANO Nicla
(syllabus)
Overview of the fundamental aspects of cell and developmental biology, biological model sused. The differentiated stateof the cells: characterization. Function of genes in the processes of determination and differentiation: Equivalence of the genome of the different cell types. Development control at the level of chromatin organization, transcription, RNA maturation, maturation and transport of RNA, translation, maturation of proteins. Morphogenetic factors and their influence on gene expression: transcription factors and growth factors. Cellular interactions in development: embryonic induction, the role of the cell surface, the extracellular matrix and soluble co-factors, differential affinity of the cells in the development, intercellular recognition, receptors, cadherins. Inductors embryogenesis for primary, secondary, tertiary, etc. Control of the development for the distribution of gradients of morphogenetic factors in vertebrates. Grid’s development and activation of homeotic genes and differential gene expression. The homeotic selector genes in Drosophila and vertebrates, differentiated cells and maintenance of the differentiated state of tissue stem cells and differentiation potential. Examples of organogenesis and organ regeneration: development and differentiation of the axis and the limb, limb regeneration, development and regeneration of the tegument, regeneration and new medical technologies (medical aesthetics); development and regeneration of the eye, development and regeneration of the digestive system. Development and evolution of the hematopoietic system, heart and regeneration. Cloning procedures. Organization of tissue and stem cells: primary oocytes as cellular source for the treatment of infertility and tissue regeneration. Oncogenes, oncogenes, tumor suppressor cancer gene. The tumor cell migration through the tissues. Immunotherapies as new avantaments for cancer cure.
(reference books)
S.F. Gilbert, "Developmental Biology", Zanichelli (most recent edition) - C. Lewin "Cellule", Zanichelli
further lectures: CITOLOGIA ed ISTOLOGIA Dini & Romano et al (2021), Idelson-Gnocchi
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