PRANTERA Giorgio
(syllabus)
DEVELOPMENTAL GENETICS AND EPIGENETICS (6 cfu)
Developmental Genetics (2 cfu)
Genetic methods to dissect development Drosophila melanogaster as a model system Maternal effect genes and zygotic genes Anteroposterior coordinates Dorsoventral coordinates The terminal system Gap genes Pair rule genes Segment polarity genes Selector genes
Genetic sex determination Drosophila X/A ratio Sex lethal gene Dosage compensation Mammals sxr gene (TDF) Dosage compensation
Epigenetics (4 cfu) Epigenetic inheritance Genomic imprinting Insects Mammals Facultative heterochromatinization Insects Mammals Position effect variegation (PEV) Paramutation in plants Molecular mechanisms governing epigenetic phenomena Chromatin remodeling Heterochromatin proteins Histone modifications DNA methylation Non coding RNAs
(reference books)
P. Lawrence: “The making of a fly”. Blackwell editore Goldberg et al.: “Genetics - from genes to genomes”. McGraw-Hill. 7th ed. USA Allis, Jenuwein, Reinberg, Caparros: "Epigenetics". Cold Sprig Harbor press
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