Teacher
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MERENDINO Nicolo'
(syllabus)
Proteins: amino acids, peptide bond. Primary structure. Secondary structure: alpha helix, beta structure. Protein fibrose: keratin, collagen, elastin. Tertiary structure: globular proteins, protein stability and folding. Quaternary structure. Myoglobin. Hemoglobin: structure, heme (synthesis and degradation), oxygen bond, bond cooperativity, 2,3-bisphosphoglycerate, allosteric regulation. Pathological hemoglobins. Enzymes: introduction to enzymes: holoenzyme, apoenzyme, cofactors, classification, substrate specificity. Enzymatic kinetics, Michaelis-Menten equation, Km, Kcat and Kcat / Km. Enzymatic inhibition: competitive, non-competitive, mixed. Mechanism of action of serine proteases. Carbohydrates: references to monosaccharides and disaccharides of biological interest. Interconversion of sugars. Structural polysaccharides (cellulose and chitin). Deposit polysaccharides (starch, glycogen). Krebs cycle. Glycoprotein: structure and function. Nucleotide formation. Blood groups. Lipids: fatty acids, triglycerides, glycerophospholipids, sphingolipids, cholesterol, lipoproteins. Properties of lipid aggregates, micelles and liposomes and lipoproteins. Biological membranes: chemical composition, membrane structure. Movement of molecules through membranes, pores and channels. Active and passive transport simporto, antiporto etc. Water-soluble vitamin: general, definition and relationship with coenzymatic activity. Fat-soluble vitamins (A; D; E; K). For each vitamin: chemical structure, any biochemical precursors, deficiency effects, biochemical mechanism of action.
(reference books)
1) Lecture notes.
2) I principi di biochimica di Lehninger di David L. Nelson, Michael M. Cox Zanichelli Editore ISBN: 8808920690
In alternativa.
3) La Chimica Organica e le macromolecole biologiche, di Butera-Lauricella Piccin Nuova Libraria ISBN:978-88-299-3057-9
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