CHIMICA ORGANICA
(objectives)
EXPECTED LEARNING RESULTS
Knowledge of the principles governing the formation of the chemical bond, using traditional theories (valence bond theory) and advanced theories (theory of molecular orbital and quantum mechanics ). Knowledge of nomenclature and classification (theory of functional groups) of organic molecules, with particular attention to the association between the family of organic molecules and biological and chemical-physical properties. Knowledge of the reactivity of organic molecules and experimental parameters capable of controlling thermodynamics and kinetics of organic transformations. Knowledge of the relationship between organic molecules and the origin of life.
In addition to the knowledge gained through the study of organic chemistry, students will be able to apply the acquired concepts for the resolution of practical exercises related to the identification and classification of substances based on Their activity on the body, the effect of chirality on pharmacological activity, the possibility of separating organic isomers and the general methodologies for their analysis and their recognition.
Making judgments: The course offers links to other disciplines (Physics, General Chemistry, Biochemistry, Molecular Biology, Computational Chemistry and Genetics) by providing an integrated knowledge. The student's critical judgment will be stimulated by constantly referring to the reading of recent studies published in scientific journals, questioning the current issues related to some of the core concepts of the discipline. Thanks to the multi-disciplinary and interdisciplinary nature of organic chemistry, it will be also possible to link the acquired concepts to other disciplines, allowing the student to form his own autonomy of judgment about the effectiveness of an integrated scientific approach.
Communication skills: At the end of each part of the course, the students will be invited to form working groups to develop solutions and compete with others in solving practical exercises. The educational gain is aimed at increasing the communication skills and the ability to know how to work in a group, all aimed at consolidating the acquired concepts.
Learning Skills: Students' learning abilities will be evaluated during the course of the course by exonerary tests that will allow you to individually monitor the maturation state of the knowledge, highlighting the student's ability to return.
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Teacher
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BOTTA Lorenzo
(syllabus)
Alkanes and cycloalkanes. Introduction. Structure. Hybridization sp3. Nomenclature. Physical properties. Structural isomerism. Conformational analysis (ethane, cyclohexane). Stability of cycloalkanes (angular tension, torsional tension, steric tension). Cyclohexane derivatives (cis-trans stereoisomerism). Bicyclic and polycyclic alkanes. Natural role and applications of alkanes.
Alkenes. Introduction. Structure. Hybridization sp2. Nomenclature. Physical properties. Stability (hydrogenation heat, combustion heat). Nomenclature system (E) - (Z) for alkenes. Cycloalkenes. Biological function.
Alkynes. Introduction. Structure. Hybridization sp. Nomenclature. Physical properties.
Functional groups and classes of organic compounds. Alkyl halides. Alcohols. Ethers. Amines. Aldehydes and ketones. Carboxylic acids. Esters and amides. Introduction. Structure. Nomenclature. Physical properties.
Stereochemistry. Introduction. Carbon chirality. Enantiomers and chiral molecules. Graphic representation. Nomenclature (R) (S). Optical activity (specific rotary power, racemic definition, optical purity). Diastereoisomers (meso compounds).
Aromatic compounds. Introduction. Benzene. Structure and stability. Huckel's rule. Other aromatic compounds. Nomenclature of benzene derivatives. Induction and resonance phenomena. Heterocyclic aromatic compounds. Aromatic compounds in biochemistry.
Carbohydrates. Classification. Monosaccharides. Mutarotation and formation of glucosides. Configuration D or L. Disaccharides. Polysaccharides.
Protein. Structure of the aminoacids. Nomenclature. Peptide bond. Oligopeptides.
Nucleic acids. Purine and pyrimidine nucleic bases. Nucleoside. Nucleotides. Oligonucleotides.
Lipids.
Module B. REACTIVITY
Alkane and cycloalkane reactions. Chlorination of methane. Free radicals. Stability and structure. Thermodynamics and kinetics. Halogenation of higher alkanes.
Nucleophilic substitution reactions. SN2 reaction. SN1 reaction. Mechanisms and stereochemical trends. Effects of the solvent and the leaving group. Elimination reactions. Reaction E1. Reaction E2. Competition between replacement and elimination.
Reactions of aromatic compounds. Electrophilic aromatic substitution. Mechanism. Benzene halogenation. Effect of substituents.
(reference books)
Chimica Organica Seconda Edizione, a cura di Bruno Botta, edi-ermes
Chimica Organica Essenziale, a cura di Bruno Botta, edi-ermes
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Dates of beginning and end of teaching activities
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From 26/09/2021 to 20/01/2022 |
Delivery mode
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Traditional
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Attendance
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not mandatory
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