13688 GENETICA DELLO SVILUPPO E EPIGENETICA in Cellular and Molecular Biology LM-6 PRANTERA Giorgio
(syllabus)
DEVELOPMENTAL GENETICS AND EPIGENETICS
(6 cfu)
Developmental Genetics (2 cfu)
Genetic methods to dissect development
Drosophila melanogaster as a model system
Maternal effect genes and zygotic genes
Anteroposterior coordinates
Dorsoventral coordinates
The terminal system
Gap genes
Pair rule genes
Segment polarity genes
Selector genes
Genetic sex determination
Drosophila
X/A ratio
Sex lethal gene
Dosage compensation
Mammals
sxr gene (TDF)
Dosage compensation
Epigenetics (4 cfu)
Epigenetic inheritance
Genomic imprinting
Insects
Mammals
Facultative heterochromatinization
Insects
Mammals
Position effect variegation (PEV)
Paramutation in plants
Molecular mechanisms governing epigenetic phenomena
Chromatin remodeling
Heterochromatin proteins
Histone modifications
DNA methylation
Non coding RNAs
(reference books)
P. Lawrence: “The making of a fly”. Blackwell editore
Hartwell LH et al.: “Genetics - from genes to genomes”. McGraw-Hill.
Allis, Jenuwein, Reinberg, Caparros: "Epigenetics". Cold Sprig Harbor press
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