Teacher
|
PROIETTI DE SANTIS Luca
(syllabus)
Introduction to pharmacogenetics and pharmacogenomics. Human genome sequencing and inter-individual variability. Individual variability in responses to drug therapy (efficacy and tolerability). Genes that influence drug response: genes coding for proteins involved in drug bioavailability (pharmacokinetics); genes that code for the therapeutic target of the drug (pharmacodynamics). Allelic variants in the human population. Polymorphisms of enzymes responsible for drug metabolism. Polymorphisms / mutations of the genes coding for the therapeutic target of the drug. Polygenic complexity and modulators of the action of a drug. Predictive Medicine and Personalized Therapy. Sequencing of tumor genomes and selection of tumor inhibitors. Identification of biological targets with diagnostic, prognostic and therapeutic value.
(reference books)
The course does not have a single reference text as it is not available. Therefore the teacher to deepen the topics covered on the following texts:- Chimica farmaceutica (Patrick) di Edises - Le basi farmacologiche della terapia (Goodman & Gilman) - Principles of Pharmacogenetics and Pharmacogenomics, Edited by Russ B. Altman, Stanford University, California, David Flockhart, Indiana University, David B. Goldstein, Duke University, North Carolina, Cambridge University Press. In addition the teacher will provide specific scientific articles during the course
|