Program: Introduction to pharmacogenetics and pharmacogenomics. Sequencing of the human genome and interindividual variability. Individual variability in responses to drug therapy (efficacy and tolerability). Genes that influence drug response: genes encoding proteins involved in the bioavailability of the drug (pharmacokinetics); genes that code for the therapeutic target of the drug (pharmacodynamics). Allelic variants in the human population. Polymorphisms of the enzymes responsible for the metabolism of drugs. Polymorphisms / mutations of the genes coding for the therapeutic target of the drug.
Polygenic complexity and modulators of the action of a drug. Predictive medicine and personalized therapy. Sequencing of tumor genomes and selection of tumor inhibitors. Identification of biological targets with diagnostic, prognostic and therapeutic value.

Articles and slides provided by the teacher. slides could be dowloaded from dropbox
https://www.dropbox.com/it/ (username: farmacogenetica@email.it; password: farmacogenetica)