PRANTERA Giorgio
(syllabus)
GENETICS (9 cfu)
The Mendel's analysis Genetic variability The law of segregation The law of independent assortment Genes and alleles: the concept of polymorphism Extensions of mendelian inheritance Variations of dominance relationships Multiple alleles Pleiotropy Multifactorial inheritance Inheritance of quantitative traits The Chromosome theory Mitosis and meiosis Sex linked inheritance Meiosis and Mendel's laws Linkage and recombination Gene linkage Crossing over Χ2 statistical test Genetic maps Three point test Mitotic recombination and genetic mosaicism The DNA is the molecule of the heredity The experiments that designated DNA as the genetic material The Watson and Crick model DNA replication DNA recombination The gene at work The mutations Genetic dissection through mutations The one gene-one enzyme hypothesis Complementation test The gene fine structure The Benzer's experiments The gene expression The genetic code Transcription Translation The eukaryotic chromosome The structure of chromatin The radial loop model Centromeres Telomeres Nucleolus organizing regions (NORs) Chromosome rearrangements Structural changes Deletions Duplications Inversions translocations Mobile elements Changes in chromosome number Polyploidy Aneuploidy Genetic analysis in bacteria Transformation Conjugation Transduction Recombination mapping Gene Regulation in prokaryotes Regulation of Lac genes The operon theory Regulation of Tryptophan genes Attenuation Gene regulation in eukaryotes Transcriptional regulation Posttranscriptional regulation The role of chromatin structure Epigenetic inheritance Euchromatin and heterochromatin Position effect variegation X chromosome inactivation in mammals Recombinant DNA techniques and genomics DNA manipulation Nucleic acid hybridization PCR Gene cloning DNA sequencing The sequencing of the genomes SNPs Microsatellites Genetic analysis of populations How to calculate the frequencies of alleles How to calculate the frequencies of genotypes The Hardy-Weinberg law Changes in allele frequencies How the populations evolve
(reference books)
Textbooks: Hartwell LH et al.: “Genetics - from genes to genomes”, 3rd edition, McGraw-Hill.
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