LEARNING OBJECTIVES

The course introduces the fundamental concepts and experimental approaches to the study of cytogenetics, a branch of genetics that analyzes the structure of the chromosomes to determine the relationship existing between the hereditary and specific karyotypes characters.
The course aims to consolidate and expand the knowledge base on chromatin structure and its intranuclear organization, the metaphase chromosome as well as its specialized structures such as centromere, telomere and fragile sites and their role in maintaining genome stability. The course also aims to address the study of human chromosomal instability syndromes and the role of the biologist in their diagnosis using classical and molecular cytogenetics techniques.
It also provides a basis for specialized studies such as the analysis of chromosomal aberrations in biological dosimetry and the use of the Comet test in genotoxicity. In particular, these issues are provided in the laboratory practice.