MESCHINI Roberta

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Martedì dalle 14.00 alle 15 ma preferibilmente per appuntamento da definire inviando una e-mail a meschini@unitus.it

Curriculum

Roberta Meschini Dipartimento di Scienze Ecologiche e Biologiche, Università degli Studi della Tuscia, Via San Camillo de Lellis, s.n.c. 01100 Viterbo Tel. +39 0761 357207, +39 0761 357258 Fax +39 0761 357343 e-mail: meschini@unitus.it Titoli Accademici 1988 Laurea in Scienze Biologiche presso la Facoltà di Scienze Matematiche, Fisiche e Naturali dell’Università degli Studi “La Sapienza” di Roma. Titolo della tesi sperimentale: “Studio sulla predittività per la cancerogenesi e mutagenesi di una linea epiteliale epatica di hamster Cinese con attività metaboliche esogene”. Votazione: 110/110 e lode. 1995 Specializzazione in Genetica Applicata presso la Facoltà di Scienze Matematiche, Fisiche e Naturali dell’Università degli Studi “La Sapienza” di Roma. Titolo della tesi sperimentale: “Frammenti ad alto peso molecolare (HMW) mediatori di apoptosi e/o delle aberrazioni cromosomiche?” Votazione: 70/70 e lode. Posizione attuale Ricercatore confermato per il settore scientifico-disciplinare BIO/18 del Dipartimento di Scienze Ecologiche e Biologiche dell’Università degli Studi della Tuscia, ed incaricato con affidamento a titolo gratuito dell’insegnamento di Citogenetica e Laboratorio di Metodologie Genetiche rispettivamente nei corsi di Laurea Magistrale in Biologia Cellulare e Molecolare e Laurea di Base in Scienze Biologiche. Borse di Studio 1987 Risulta vincitrice di una borsa di studio dell’Università Statale di Leiden (Olanda) di cui usufruire per un periodo di tre mesi 1988 Risulta vincitrice di una borsa di studio della European Science Foundation di cui usufruire all’estero per un periodo di un anno. 1989 Risulta vincitrice di una borsa di studio dell’Unione Europea di cui usufruire all’estero per un periodo di sei mesi. 1990 Risulta vincitrice di una borsa di studio dell’Università Statale di Leiden (Olanda) di cui usufruire per un periodo di sei mesi. Soggiorni all’estero Università Statale di Leiden (Olanda), Dipartimento di Radiogenetica e Mutagenesi Chimica (laboratorio del Prof. A.T. Natarajan). Apprende tecniche molecolari per lo studio della riparazione del DNA al livello di singoli geni che differiscono per il loro stato trascrizionale. Karolinska Institute di Stoccolma (Svezia), Institute of Environmental Medicine, Division of Toxicology. Apprende la tecnica dell’elettroforesi su gel di agarosio in campo pulsato (PFGE) per l’analisi molecolare della formazione dei frammenti di DNA ad alto peso molecolare nel processo di morte cellulare apoptotica. Partecipazione a Progetti di Ricerca Nazionali ed Internazionali Come collaboratore 1. Progetto Finalizzato “Medicina Preventiva e Riabilitativa” Consiglio Nazionale delle Ricerche (CNR) No. 82.0225 6 2. Contratto UE – Genetic Effects of Environmental Chemicals: Assessment of mutagnic risk of environmental chemicals by cytogenetic methods. 3. Contratto UE EV5V-CT91-006: Development and validation of metabolic activation systems for mutagenicity testing not using vertebrate animals. 4. Contratto UE B17 0039-C(EBD): Studies on basic and applied aspects of radiation-induced chromosomal aberrations. 5. Contratto UE F13 PCT920031: Studies on radiation induced chromosome aberrations in mammalian cells: Applied aspects. 6. Contratto UE COSU-CT92-0022: Health effect post-Chernobyl. Biological dosimetry including cytogenetics. 7. Contratto UE B92/B4-3040/11/016322: Evaluation and validation of the methodology of using mammalian cell lines with endogenous metabolic activities as alternative test procedure to reduce the use of animals. 8. Contratto UE ENV4 CT-0169: Apoptosis, a relevant biological end-point to rifine and improve in vitro assessment of cytotoxicity and genotoxicity of environmental pollutants. 9. Contratto UE EV5V-CT94-0508: Development of new sensitive end-points to assess cytotoxicity and genotoxicity pollutants in the nervous system. 10. Contratto UE FIS5-1999-071: Mechanisms of formation of ionizing radiation-induced chromosomal aberrations: impact of repair pathways and nuclear architecture. 11. Contratti Agenzia Spaziale Italiana (ASI) No. RS 113; ASI 92 RS 145; ARS/99/49; I/R/119/00; I/R/108/01 (1994-2001): Ricerche sul danno cromosomico indotto dalle radiazioni ionizzanti nello spazio extraterrestre. 12. Contratto UE 14969.1999.04: Application of molecular and cytogenetic endpoints in haematoxicology. 13. Contratto UE FOOD-CT-2003-505609: Dietary exposures to polycyclic aromatic hydrocarbons and DNA damage (DIEPHY). 14. Contratto Philip Morris USA, Inc. and Philip Morris International and University of Tuscia. 15. Contratto Sigma-Tau: Analisi del meccanismo d’induzione della morte cellulare da parte della sostanza ST-DS2323. 16. Contratto UE FUNCFOOD 245030 Impact of agents with potential use in functional foods on biomarkers for induction of age related diseases. Come responsabile 1. Joint Reserch Projects for the exchanges of researcher within the XVII Executive Programme of Scientific and Technological Co-operation between Italy and Ungary: Individual radiation sensitivity in cancer patients and healthy individuals. 2. RENEB: Realizing the European Network of Biodosimetry. Attività di Referee E' Referee per la rivista internazionale Mutagenesis. Attività didattica Incarichi di docenza Cultore della materia e membro della Commissione di esame di Genetica per il Corso di Laurea in Scienze Biologiche presso il Dipartimento di Scienze Ecologiche e Biologiche (DEB) dell’Università degli Studi della Tuscia; E’ titolare del corso di “Citogenetica” per il Corso di Laurea Magistrale in Biologia Cellulare e Molecolare presso il Dipartimento di Scienze Ecologiche e Biologiche (DEB) dell’Università degli Studi della Tuscia (6 crediti). E’ titolare del corso di “Laboratorio di Metodologie Genetiche” per il Corso di Laurea in Scienze Biologiche presso il Dipartimento di Scienze Ecologiche e Biologiche (DEB) dell’Università degli Studi della Tuscia (6 crediti). Attività di Correlatore e Relatore di Tesi di Laurea e di Tutor di Tesi di Dottorato E’ stata correlatore, relatore, tutor di più di 80 tesi di Laurea Triennale, Magistrale o di Dottorato. E’ membro della Commissione Didattica del Corso di Laurea Triennale in Scienze Biologiche e Magistrale in Biologia Cellulare e Molecolare. Attività di Ricerca Vasta esperienza nel campo della Radiogenetica e della Mutagenesi Chimica. Principali ambiti di ricerca: Studio dei meccanismi di riparazione del danno al DNA indotto da agenti chimici e fisici in linee cellulari; Studio della risposta al danno al DNA e del mantenimento della stabilità genomica e cromosomica dopo esposizione ad agenti chimici e fisici in cellule umane normali e derivanti da sindromi genetiche; Studio della radiosensibilità in cellule derivanti da individui affetti dalla sindrome genetica Ataxia telangiectasia; Studio di potenziali organismi animali e vegetali come bioindicatori di genotossicità. List of publications 1. De Salvia R, Meschini R, Fiore M, Polani S, Palitti F, Carluccio MA, Turchi G. 1988 Induction of sister-chromatid exchanges by procarcinogens in metabolically competent Chinese hamster epithelial liver cells. Mutation Research, 207, 69-75. 2. Meschini R, Quaranta MT, Fiore M, Polcaro C, Possagno E, Palitti F. 1988 Chromosomal damage induced by maleic hydrazide in mammalian cells in vitro and in vivo. Mutation Research, 204, 645-648. 3. Sankaranarajanan K, van Duyn A, Loos MJ, Meschini R, Natarajan AT. 1990 Effects of sodium butyrate on X-ray and bleomycin-induced chromosome aberrations in human peripheral blood lymphocytes. Genetical Research, 56, 267-276. 4. van Hoffen A, Venema J, Meschini R, van Zeeland AA, Mullenders LH. 1995 Transcription-coupled repair removes both cyclobutane pyrimidine dimers and 6-4 photoproducts with equal efficiency and in a sequential way from transcribed DNA in xeroderma pigmentosum group C fibroblasts. EMBO Journal, 14, 360-367. 5. Basic-Zaninovic TB, Meschini R, Calcagnile A, Palombo F, D’Errico M, Proietti De Santis L, Dogliotti E. 1995 Strand bias of ultraviolet light-induced mutations in a transcriptionally active gene in human cells. Molecular Carcinogenesis, 14, 214-225. 6. Meschini R, Bastianelli R, Palitti F. 1996 The diplochromosome of endoreduplicated cells: a new approach to highlight the mechanism of sister chromatid exchange. Chromosoma, 105, 50-54. 7. Sgura A, Meschini R, Antoccia A, Palitti F, Obe G, Tanzarella C. 1996 DNA damage induced by UV light affects restriction endonuclease recognition sites: correlation between effects at chromosomal level and naked DNA. Mutagenesis, 11, 463-466. 8. Abelli L, Baldassini MR, Meschini R, Mastrolia L. 1998 Apoptosis of thymocytes in developing sea bass Dicentrarchus labrax (L.). Fish and Shellfish Immunology, 8, 13-24. 9. Stoilov L*, Darroudi F*, Meschini R*, van der Schans G, Mullenders LH, Natarajan AT. 2000 Inhibition of repair of X-ray-induced DNA double-strand breaks in human lymphocytes exposed to sodium butyrate. International Journal of Radiation Biology, 76, 1485-1491. *First authors with equal contribution. 10. Carloni M*, Meschini R*, Ovidi L, Palitti F. 2001 PHA-induced cell proliferation rescues human peripheral blood lymphocytes from X-ray-induced apoptosis. Mutagenesis, 16, 115-120. *First authors with equal contribution. 11. Bassi L, Carloni M, Fonti E, Palma de la Pena N, Meschini R, Palitti F. 2002 Pifithrin-alpha, an inhibitor of p53, enhances the genetic instability induced by etoposide (VP16) in human lymphoblastoid cells treated in vitro. Mutation Research, 499, 163-176. 12. Bassi L*, Carloni M*, Meschini R*, Fonti E, Palitti F. 2003 X-irradiated human lymphocytes with unstable aberrations and their preferential elimination by p53/survivin-dependent apoptosis. International Journal of Radiation Biology, 79, 943-954. *First authors with equal contribution. 13. D’Errico M, Teson M, Calcagnile A, Corona R, Didona B, Meschini R, Zambruno G, Dogliotti E. 2004 Characterization of the ultraviolet B and X-ray response of primary cultured epidermal cells from patients with disseminated superficial actinic porokeratosis. British Journal of Dermatology, 150, 47-55. 14. Malerba I, Gribaldo L, Diodovich C, Carloni M, Meschini R, Bowe G, Collotta A. 2005 Induction of apoptosis and inhibition of telomerase activity in human bone marrow and HL-60 p53 null cells treated with anti-cancer drugs. Toxicology in vitro, 19, 523-532. 15. Belloni P, Meschini R, Czene S, Harms-Ringdahl M, Palitti F. 2005 Studies on radiation-induced apoptosis in G0 human lymphocytes. International Journal of Radiation Biology, 81, 587-599. 16. Meschini R, Marotta E, Berni A, Filippi S, Fiore M, Mancinelli P, Natarajan AT, Palitti F. 2008 DNA repair deficiency and BPDE-induced chromosomal alterations in CHO cells. Mutation Research, 637, 93-100. 17. Berni A*, Meschini R*, Filippi S, Palitti F, De Amicis, Chessa L. 2008 L-Carnitine enhances resistance to oxidative stress by reducing DNA damage in Ataxia telangiectasia cells. Mutation Research, 650, 165-174. *First authors with equal contribution. 18. Belloni P*, Meschini R*, Lewinska D, Palitti F. 2008 Apoptosis preferentially eliminates irradiated G0 human lymphocytes bearing dicentric chromosomes. Radiation Research, 169, 181-187. *First authors with equal contribution. 19. Belloni P, Meschini R, Palitti F. 2008 Effects of storage conditions of human whole blood on the viability of lymphocytes. International Journal of Radiation Biology, 84, 613-619. 20. Meschini R, Berni A, Ortenzi V, Mancinelli P, Palitti F. 2010 Relation between DNA repair, apoptosis and chromosomal aberrations in presence of pifithrin-alfa, an inhibitor of p53. Mutation Reserch, 701, 92-97. 21. Meschini R, Berni A, Marotta E, Filippi S, Fiore M, Mancinelli P, Natarajan AT, Palitti F. 2010 DNA repair mechanisms involved in the removal of DBPDE-induced lesions leading to chromosomal alterations in CHO cells. Cytogenetic and Genome Reserch, 128, 124-130. 22. Paris L, Cordelli E, Eleuteri P, Grollino MG, Pasquali E, Ranaldi R, Meschini R, Pacchierotti F. 2011 Kinetics of gamma-H2AX induction and removal in bone marrow and testicular cells of mice after X-ray irradiation. Mutagenesis, 26, 563-572. 23. Ortenzi V1, Meschini R1*, Berni A, Mancinelli P, Palitti F. 2011 Study on X-ray-induced apoptosis and chromosomal damage in G2 human lymphocytes in the presence of an inhibitor of p53, pifithrin-. Mutation Research, 276, 29-35. 1First authors with equal contribution *Corresponding author 24. Maria Rosaria Grossi, Andrea Berni, Gaetano Pepe, Silvia Filippi, Roberta Meschini, Cristiano Papeschi, Adayapalam T. Natarajan and Fabrizio Palitti. 2014 Evaluation of the effects of ellagic acid (EA) on 7,12-dimethylbenz(α) anthracene (DMBA) induced micronuclei in mammalian cells in vitro and in vivo. Toxicology Letters, 224, 240-245. 25. Bianca Gustavino, Roberta Meschini, Giulia Franzetti, Paolo Gratton, Giuliana Allegrucci, Valerio Sbordoni,. 2014 Genotoxicity testing for radon exposure: Dolichopoda as potential bio-indicator of confined environments. Current Zoology 60, 299–307. 26. Meschini R*, Morucci E, Berni A, Lopez-Martinez W, Palitti F. 2015 Role of chromatin modulation by the histone deacetylase inhibitor Trichostatin A on the radio-sensitivity of ataxia telangiectasia (A-T). Mutation Research, 777, 52-59. * Corresponding author 27. Roberta Meschini, Silvia Filippi, Romina Molinari, Lara Costantini, Giovanni Bonafaccia, Nicolò Merendino. 2015 Pasta Containing Tartary Buckwheat Sprouts Prevent DNA Damage in Spontaneously Hypertensive Rats. International Journal Food Sciences and Nutrition, 66, 574-578. 28. Paris L, Giardullo P, Leonardi S, Tanno B, Meschini R, Cordelli E, Benassi B, Longobardi MG, Izzotti A, Pulliero A, Mancuso M, Pacchierotti F. 2015 Transgenerational inheritance of enhanced susceptibility to radiation-induced medulloblastoma in newborn Ptch1+/- mice after paternal irradiation. Oncotarget, 6, 36098-36112. 29. Meschini R*, Berni A, Filippi S, Pepe G, Grossi MR, Natarajan AT, Palitti F. 2015 The micronucleous assay in mammalian cells in vitro to assess health benefits of various phytochemicals. Mutation Research Genetic Toxicology and Environmental Mutagenesis, 793, 79-85. * Corresponding author 30. Kuzminsky E, Meschini R, Terzoli S, Pavani L, Silvestri C, Choury Z, Scarascia-Mugnozza G. 2016 Isolation of Mesophyll Protoplasts from Mediterranean Woody Plants for the Study of DNA Integrity under Abiotic Stress. Frontiers in Plant Sciences, Aug 15, 7, 1168. 31. Maria Piane, Anna Molinaro, Annarosa Soresina, Silvia Costa, Marianna Maffeis, Aldo Germani, Lorenzo Pinelli, Roberta Meschini, Alessandro Plebani, Luciana Chessa, Roberto Micheli. 2016 Novel compound heterozygous mutations in a child with Ataxia-Telangiectasia showing unrelated cerebellar disorders. Journal of the Neurological Sciences, 371, 48–53. 32. Monteiro Gil O, Vaz P, Romm H, De Angelis C, Antunes AC, Barquinero JF, Beinke C, Bortolin E, Burbidge CI, Cucu A, Della Monaca S, Domene MM, Fattibene P, Gregoire E, Hadjidekova V, Kulka U, Lindholm C, Meschini R, M'Kacher R, Moquet J, Oestreicher U, Palitti F, Pantelias G, Montoro Pastor A, Popescu IA, Quattrini MC, Ricoul M, Rothkamm K, Sabatier L, Sebastià N, Sommer S, Terzoudi G, Testa A, Trompier F, Vral A. 2017 Capabilities of the RENEB network for research and large scale radiological and nuclear emergency situations. International Journal of Radiation Biology, 93(1), 136-141. 33. Brzozowska B, Ainsbury E, Baert A, Beaton-Green L, Barrios L, Barquinero JF, Bassinet C, Beinke C, Benedek A, Beukes P, Bortolin E, Buraczewska I, Burbidge C, De Amicis A, De Angelis C, Della Monaca S, Depuydt J, De Sanctis S, Dobos K, Domene MM, Domínguez I, Facco E, Fattibene P, Frenzel M, Monteiro Gil O, Gonon G, Gregoire E, Gruel G, Hadjidekova V, Hatzi VI, Hristova R, Jaworska A, Kis E, Kowalska M, Kulka U, Lista F, Lumniczky K, Martínez-López W, Meschini R, Moertl S, Moquet J, Noditi M, Oestreicher U, Orta Vázquez ML, Palma V, Pantelias G, Montoro Pastor A, Patrono C, Piqueret-Stephan L, Quattrini MC, Regalbuto E, Ricoul M, Roch-Lefevre S, Roy L, Sabatier L, Sarchiapone L, Sebastià N, Sommer S, Sun M, Suto Y, Terzoudi G, Trompier F, Vral A, Wilkins R, Zafiropoulos D, Wieser A, Woda C, Wojcik A. 2017 RENEB accident simulation exercise. International Journal of Radiation Biology, 93(1), 75-80. 34. Kulka U, Abend M, Ainsbury E, Badie C, Barquinero JF, Barrios L, Beinke C, Bortolin E, Cucu A, De Amicis A, Domínguez I, Fattibene P, Frøvig AM, Gregoire E, Guogyte K, Hadjidekova V, Jaworska A, Kriehuber R, Lindholm C, Lloyd D, Lumniczky K, Lyng F, Meschini R, Mörtl S, Della Monaca S, Monteiro Gil O, Montoro A, Moquet J, Moreno M, Oestreicher U, Palitti F, Pantelias G, Patrono C, Piqueret-Stephan L, Port M, Prieto MJ, Quintens R, Ricoul M, Romm H, Roy L, Sáfrány G, Sabatier L, Sebastià N, Sommer S, Terzoudi G, Testa A, Thierens H, Turai I, Trompier F, Valente M, Vaz P, Voisin P, Vral A, Woda C, Zafiropoulos D, Wojcik A. 2017 RENEB - Running the European Network of biological dosimetry and physical retrospective dosimetry. International Journal of Radiation Biology, 93(1), 2-14. 35. Trompier F, Baumann M, Barrios L, Gregoire E, Abend M, Ainsbury E, Barnard S, Barquinero JF, Bautista JA, Brzozowska B, Perez-Calatayud J, De Angelis C, Domínguez I, Hadjidekova V, Kulka U, Mateos JC, Meschini R, Monteiro Gil O, Moquet J, Oestreicher U, Montoro Pastor A, Quintens R, Sebastià N, Sommer S, Stoyanov O, Thierens H, Terzoudi G, Villaescusa JI, Vral A, Wojcik A, Zafiropoulos D, Roy L. 2017 Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation. International Journal of Radiation Biology, 93(1), 118-126. 36. Oestreicher U, Samaga D, Ainsbury E, Antunes AC, Baeyens A, Barrios L, Beinke C, Beukes P, Blakely WF, Cucu A, De Amicis A, Depuydt J, De Sanctis S, Di Giorgio M, Dobos K, Dominguez I, Duy PN, Espinoza ME, Flegal FN, Figel M, Garcia O, Monteiro Gil O, Gregoire E, Guerrero-Carbajal C, Güçlü İ, Hadjidekova V, Hande P, Kulka U, Lemon J, Lindholm C, Lista F, Lumniczky K, Martinez-Lopez W, Maznyk N, Meschini R, M'kacher R, Montoro A, Moquet J, Moreno M, Noditi M, Pajic J, Radl A, Ricoul M, Romm H, Roy L, Sabatier L, Sebastià N, Slabbert J, Sommer S, Stuck Oliveira M, Subramanian U, Suto Y, Que T, Testa A, Terzoudi G, Vral A, Wilkins R, Yanti L, Zafiropoulos D, Wojcik A. 2017 RENEB intercomparisons applying the conventional Dicentric Chromosome Assay (DCA). International Journal of Radiation Biology, 93(1), 20-29. 37. Elizabeth Ainsbury, Christophe Badie, Stephen Barnard, Grainne Manning, Jayne Moquet, Michael Abend, Ana Catarina Antunes, Lleonard Barrios, Celine Bassinet, Christina Beinke, Emanuela Bortolin, Lily Bossin, Clare Bricknell, Kamil Brzoska, Iwona Buraczewska, Carlos Huertas Casta~no, Zina Cemusova, Maria Christiansson, Santiago Mateos Cordero, Guillaume Cosler, Sara Della Monaca, Franc¸ois Desangles, Michael Discher, Inmaculada Dominguez, Sven Doucha-Senf, Jon Eakins, Paola Fattibene, Silvia Filippi, Monika Frenzel, Dimka Georgieva, Eric Gregoire, Kamile Guogyte, Valeria Hadjidekova, Ljubomira Hadjiiska, Rositsa Hristova, Maria Karakosta, Enik}o Kis, Ralf Kriehuber, Jungil Lee, David Lloyd, Katalin Lumniczky, Fiona Lyng, Ellina Macaeva, Matthaeus Majewski, S. Vanda Martins, Stephen W.S. McKeever, Aidan Meade, Dinesh Medipally, Roberta Meschini, Radhia M’kacher, Octavia Monteiro Gil, Alegria Montero, Mercedes Moreno, Mihaela Noditi, Ursula Oestreicher, Dominik Oskamp, Fabrizio Palitti, Valentina Palma, Gabriel Pantelias, Jerome Pateux, Clarice Patrono, Gaetano Pepe, Matthias Port, Marıa Jesus Prieto, Maria Cristina Quattrini, Roel Quintens, Michelle Ricoul, Laurence Roy, Laure Sabatier, Natividad Sebastia, Sergey Sholom, Sylwester Sommer, Albena Staynova, Sonja Strunz, Georgia Terzoudi, Antonella Testa, Francois Trompier, Marco Valente, Olivier Van Hoey, Ivan Veronese, Andrzej Wojcik and Clemens Woda. 2017 Integration of new biological and physical retrospective dosimetry methods into EU emergency response plans – joint RENEB and EURADOS inter-laboratory Comparisons. International Journal of Radiation Biology, 93(1), 99-109. 38. Terzoudi GI, Pantelias G, Darroudi F, Barszczewska K, Buraczewska I, Depuydt J, Georgieva D, Hadjidekova V, Hatzi VI, Karachristou I, Karakosta M, Meschini R, M'Kacher R, Montoro A, Palitti F, Pantelias A, Pepe G, Ricoul M, Sabatier L, Sebastià N, Sommer S, Vral A, Zafiropoulos D, Wojcik A. 2017 Dose assessment intercomparisons within the RENEB network using G0 lymphocyte prematurely condensed chromosomes (PCC assay). International Journal of Radiation Biology, 93(1), 48-57. 39. Picchietti S., Bernini C., Taddei A.R., Meschini R., Fausto A.M., Rocco L., Stocchi V., Buonocore F., Scapigliati G. 2017 Engineered nanoparticols of titanium dioxide (TIO2): uptake and biological effects in a sea bass cell line. Fish & Shellfish Immunology, 63, 53-67. 40. Botta Lorenzo, Brunori Fabrizio, Tulimieri Antonia, Piccinino Davide, Meschini Roberta*, Saladino, Raffaele*. 2017 Laccase mediated enhancement of the antioxidant activity of propolis and poplar bud exudates. ACS Omega, 2(6), 2515-2523. * Corresponding author 41. Choury Z, Meschini R, Dell’Orso A, Fardusi MJ, Mugnozza GS, Kuzminsky E. 2018 Optimized conditions for the isolation of mesophyll protoplasts along the growing season from Arbutus unedo and their use in single cell gel electrophoresis. Plant Cell, Tissue and Organ Culture 132, 535-543. 42. Filippi S, Meschini R*, Spognardi S, Papetti P, Angeletti D. 2018 Genetic effects in Helix aspersa near a coal plant revealed by the micronucleus test. Ecotoxicology 27, 234-243. * Corresponding author 43. Camerlingo C, Verde A, Manti L, Meschini R, Delfino I, Lepore M. 2018 Graphene-based raman spectroscopy for ph sensing of x-rays exposed and unexposed culture media and cells. Sensors (Switzerland) 18, 2242. 44. Meschini R, D'Eliseo D, Filippi S, Bertini L, Bizzarri BM, Botta L, Saladino R, Velotti F. 2018 Tyrosinase-Treated Hydroxytyrosol-Enriched Olive Vegetation Waste with Increased Antioxidant Activity Promotes Autophagy and Inhibits the Inflammatory Response in Human THP-1 Monocytes. Journal of Agricultural and Food Chemistry 66,12274-12284. 45. Martínez-López W, Moreno-Ortega D, Valencia-Payan J, Sammander P, Meschini R, Palitti F. 2018 Influence of chromatin remodeling in the removal of UVC-induced damage in TCR proficient and deficient Chinese hamster cells. Mutation Research - Genetic Toxicology and Environmental Mutagenesis 836, 124-131. 46. Egidi A, Filippi S, Manganello F, Lopez-Martinez W, Meschini R*. 2018 Modulation of chromatin conformation by the histone deacetylase inhibitor trichostatin A promotes the removal of radiation-induced lesions in ataxia telangiectasia cell lines. Mutation Research - Genetic Toxicology and Environmental Mutagenesis 836, 109-116. * Corresponding author 47. Botta L, Filippi S, Bizzarri BM, Meschini R, Caputo M, Proietti De Santis L, Iside C, Nebbioso A, Gualandi G, Saladino R. 2019 Oxidative nucleophilic substitution selectively produces cambinol derivatives with antiproliferative activity on bladder cancer cell lines. Bioorganic and Medicinal Chemistry Letters 29, 78-82. 48. Molino C, Filippi S, Stoppiello GA, Meschini R*, Angeletti D. 2019 In vitro evaluation of cytotoxic and genotoxic effects of Di(2-ethylhexyl)-phthalate (DEHP) on European sea bass (Dicentrarchus labrax) embryonic cell line. Toxicology in Vitro 56, 18-125. * Corresponding author E’ autore e coautore di più di 60 comunicazioni a Congressi Nazionali ed Internazionali.